SQSTM1
Gene5 papersHGNC 11280MGI 107931NCBI Gene 8878Taxon 9606
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5Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular…A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice
The supplement boosted autophagy via COPS3, enhancing megakaryocyte maturation and polyploidization without altering baseline platelet counts.The supplement boosted autophagy via COPS3, enhancing megakaryocyte maturation and polyploidization without altering baseline platelet counts.
Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy
Researchers identified ghrelin as a key metabolic factor that reduces microglial senescence and inflammation through the SHBG/JNK1/Beclin1 signaling…Researchers identified ghrelin as a key metabolic factor that reduces microglial senescence and inflammation through the SHBG/JNK1/Beclin1 signaling axis.
Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy
The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway.The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway.