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Body system83 papersUBERON 0001004

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NPJ Digital MedicineHumans

Brain signatures of BMI detect systemic disease better than BMI

Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary…Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary conditions.

The Lancet Global HealthHumans

Most COPD is underdiagnosed and linked to higher mortality

In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no…In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no COPD.

Journal of Global HealthHumans

Lung function declines in young adults in rural Uganda

FEV₁ declined by 10 mL per year across the cohort, and dropped 18 mL annually in individuals with normal baseline spirometry.FEV₁ declined by 10 mL per year across the cohort, and dropped 18 mL annually in individuals with normal baseline spirometry.

medRxivHumansPreprint

DNA methylation proxies of senescence markers track human disease and mortality

The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.

medRxivHumansPreprint

Epigenetic puberty index tracks biological aging and adult health risks

A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult…A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.