H-151
Intervention2 papers3 findingsPubChem 7616033
- Animals2
Outcomes
3Epithelial-mesenchymal transition
downin cells1Very low certainty
1 study
Epithelial-mesenchymal transition
downin cells1Very low certainty
H-151 decreases epithelial-mesenchymal transition in cells.
Cells
LAPTM5 correlates with RPE senescence and subretinal fibrosis through the LAPTM5-WWP2-OPTN mitophagy cascade and cGAS/STING activation in a D-galactose-induced aging model · GeroScience · 8 Sep 2026
Ovarian dysfunction
downin mice1Very low certainty
1 study
Ovarian dysfunction
downin mice1Very low certainty
H-151 decreases ovarian dysfunction in mice.
Animalsin Tfam mutants
Mitochondrial DNA leakage in oocytes activates cGAS-STING signaling to drive ovarian aging · Nature aging · 28 Aug 2026
Progeria
downin mice1Very low certainty
1 study
Progeria
downin mice1Very low certainty
H-151 decreases progeria in mice.
Animalsin myeloid-specific CK2α ablation mice
CK2α restriction of STING accumulation underlies systemic aging · Nature communications · 19 Aug 2026