Mitochondrial DNA
Biomarker5 papers
- Animals3
Latest
17Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · Chen G et al.
D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway
The rare sugar enhances mitophagy, blocks cGAS-STING signaling, and protects nucleus pulposus cells from senescence and apoptosis.
Experimental & molecular medicine · Zhao Z et al.
Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss
ReviewMolecular neurobiology
Increased mtDNA Polymorphism Level and Defective Mitophagy are Associated With Proinflammatory Activation in THP-1-Based Cybrids
CellsFrontiers in bioscience (Elite edition)
An Update of Oxidative Stress in Atherosclerosis with Emphasis on the LOX-1-NLRP3 Inflammasome Axis
ReviewCurrent atherosclerosis reports
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels
CellsJournal of Alzheimer's disease : JAD
Crebanine protects aged rats from anesthesia-induced cognitive deficits by restoring mitophagy
The compound suppresses mitochondrial DNA leakage and the cGAS-STING inflammatory pathway in microglial cells following sevoflurane exposure.
Research Square · Zheng G et al.
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity
Declining TFAM levels impair mitochondrial function in CD8+ T cells, driving tissue damage and weakening long-term immune protection during influenza.
bioRxiv · Navaeiseddighi Z et al.
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
ReviewReproductive medicine and biology