SERPINE1
Gene3 papers5 findingsHGNC 8583NCBI Gene 5054Taxon 9606
A review links SERPINE1 to cellular senescence in intervertebral disc degeneration and impaired osteogenesis in osteoporosis; another describes inhibited cell cycle regulation, increased extracellular matrix remodelling and inflammation.
- Humans1
- Animals1
Effects
4Osteogenesis
downin reviews1
1 study
Osteogenesis
downin reviews1
SERPINE1 impairs osteogenesis.
Reviewin osteoporosis
SERPINE1/PAI-1 in Skeletal Degeneration: A Proposed Context-Dependent Framework for Bone Remodeling Regulation · Calcified tissue international · 11 Sep 2026
Inflammation
upin reviews1
1 study
Inflammation
upin reviews1
SERPINE1 increases inflammation.
Review
SERPINE1 (PAI-1) Regulation in Mechanotransduction-Associated Cellular Senescence · Journal of cellular biochemistry · 1 Sep 2026
Extracellular matrix remodelling
upin reviews1
1 study
Extracellular matrix remodelling
upin reviews1
SERPINE1 increases extracellular matrix remodelling.
Review
SERPINE1 (PAI-1) Regulation in Mechanotransduction-Associated Cellular Senescence · Journal of cellular biochemistry · 1 Sep 2026
Cell cycle regulation
downin reviews1
1 study
Cell cycle regulation
downin reviews1
SERPINE1 inhibits cell cycle regulation.
Review
SERPINE1 (PAI-1) Regulation in Mechanotransduction-Associated Cellular Senescence · Journal of cellular biochemistry · 1 Sep 2026
Associations
1Cellular senescence
upin reviews1
1 study
Cellular senescence
upin reviews1
SERPINE1 is associated with cellular senescence.
Reviewin intervertebral disc degeneration
SERPINE1/PAI-1 in Skeletal Degeneration: A Proposed Context-Dependent Framework for Bone Remodeling Regulation · Calcified tissue international · 11 Sep 2026
Funding
National Heart, Lung, and Blood InstituteUS$1.1m1 grant since 2024