NF-κB signalling
Pathway18 papers4 findingsGO 0007249
One mouse study shows Camellia sinensis inhibits hepatic NF-κB signalling in D-galactose-induced ageing. Reviews additionally describe inhibition of the pathway by berberine, Cornus officinalis, and melatonin.
- Animals5
- Cells2
Interventions
4Camellia sinensis
downin mice1
1 study
Camellia sinensis
downin mice1
Camellia sinensis inhibits NF-κB signalling in mice.
Animalsin D-galactose-induced agingNongxiang-type Tieguanyin extractliver110 or 550 mg/kg/day8 weeks
Protective Effects of Nongxiang-Type Tieguanyin on the Liver of D-Galactose-Induced Aging C57BL/6 Mice via the NF-κB Signaling Pathway · Food science & nutrition · 29 Sep 2026
Berberine
downin reviews1
1 study
Berberine
downin reviews1
Berberine inhibits NF-κB signalling.
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026
Melatonin
downin reviews1
1 study
Melatonin
downin reviews1
Melatonin inhibits NF-κB signalling.
Reviewkidney
Melatonin and Diabetic Nephropathy: From Mechanistic Pathways to Translational Opportunities in Clinical Management · Current medicinal chemistry · 25 Sep 2026
Cornus officinalis
downin reviews1
1 study
Cornus officinalis
downin reviews1
Cornus officinalis inhibits NF-κB signalling.
Review
Cornus officinalis Fruit in the Modulation of Aging-Related Cellular Pathways: a short review · Journal of pharmacopuncture · 1 Sep 2026
Latest
18Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
Food science & nutrition · Shi H et al.
Inhibiting miR-128-3p restores muscle mass and function in aged mice
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.
bioRxiv : the preprint server for biology · Boldridge MA et al.
Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
bioRxiv · Grafton F et al.