PI3K–AKT signalling
Pathway14 papers3 findingsGO 0043491
- Animals8
- Model organisms1
- Cells2
Interventions
2N-methyl-n-nitrosourea
downin N. xanthodon cells1
1 study
N-methyl-n-nitrosourea
downin N. xanthodon cells1
N-methyl-n-nitrosourea inhibits PI3K–AKT signalling in N. xanthodon cells.
Cellsfibroblast
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026
FOXO3 overexpression
downin chickens1
1 study
FOXO3 overexpression
downin chickens1
FOXO3 overexpression inhibits PI3K–AKT signalling in chickens.
Animalsat 4 dphovaryfemales
FOXO3 overexpression delays primordial follicle activation in chickens · Poultry science · 21 Sep 2026
Associations
1Diminished ovarian reserve
downin human cells1
1 study
Diminished ovarian reserve
downin human cells1
Diminished ovarian reserve is associated with PI3K–AKT signalling in human cells.
Cellsin DOR patientsgranulosa cellfemales
[Wuzi Yanzong Pill ameliorates diminished ovarian reserve in mice by inhibiting granulosa cell apoptosis via the TGF-β1/PI3K/Akt/mTOR pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026
Latest
14FOXO3 overexpression delays primordial follicle activation in chickens
Overexpressing the transcription factor kept avian follicles dormant and suppressed PI3K and AKT signaling during early ovarian development.
Poultry science · Lan M et al.
[Wuzi Yanzong Pill ameliorates diminished ovarian reserve in mice by inhibiting granulosa cell apoptosis via the TGF-β1/PI3K/Akt/mTOR pathway]
Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice
The supplement boosted autophagy via COPS3, enhancing megakaryocyte maturation and polyploidization without altering baseline platelet counts.
Aging cell · Xu Y et al.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
bioRxiv · Torres G et al.
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.
Aging cell · Qin M et al.
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Guan X et al.
Encapsulated sustained-release whey protein improves muscle mass and strength in sarcopenic mice
A specialized encapsulation system slows protein digestion to boost muscle signaling and physical endurance in a murine sarcopenia model.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Zhang Y et al.
Arsenic triggers heart senescence in mice while quercetin counteracts the damage
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.
Toxicology and applied pharmacology · Wang H et al.