Epigenetic age
Biomarker1 paper
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19Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.
Mammalian cellular identity erodes with age through predictable chromatin drift
Imperfect maintenance of developmental chromatin constraints causes age-associated DNA methylation gains predominantly at polycomb-regulated genomic regions across mammalian tissues.
Speech clocks reflect dementia phenotypes and biological aging markers
A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.
Exercise slows epigenetic aging in breast cancer survivors
A randomized trial shows a 12-month workout program slowed DNA methylation clocks and linked with preserved cognitive health.