Insulin/IGF-1 signalling
Pathway10 papersGO 0008286
- Animals1
- Model organisms2
Latest
10USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.
Cell reports · Gordillo-García S et al.
Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges
ReviewFrontiers in nutrition
AnimalsPeer-reviewed
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.
Aging cell · Xu R et al.
Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies
ReviewDiabetes, metabolic syndrome and obesity : targets and therapy
Reframing Alzheimer's Disease Through a Redox-Metabolic Framework
ReviewInternational journal of molecular sciences