MYO6

1. MYO6 decreases autophagosome accumulation in mice.

   “loss of MVI affected autophagy/mitophagy activity in P0 hearts, leading to accumulation of autophagosomes.”

   Animalsshown by Myo6 knockout compared with heterozygous littermatesheart

   Loss of myosin VI leads to age-dependent changes in the maintenance of heart ventricle mitochondria

   bioRxiv·14 Oct 2026Preprint

1. MYO6 has no effect on AMPK signalling in mice.

   “loss of MVI, at all examined time points, did not affect the activity of AMPK”

   Animalsshown by Myo6 knockout compared with heterozygous littermatesheart

   Loss of myosin VI leads to age-dependent changes in the maintenance of heart ventricle mitochondria

   bioRxiv·14 Oct 2026Preprint

More on AMPK signalling

1. MYO6 decreases perinuclear mitochondrial clustering in mice.

   “loss of MVI affected mitochondria network organization and promoted mitochondria clustering in the perinuclear space.”

   Animalsshown by Myo6 knockout compared with heterozygous littermatesheart

   Loss of myosin VI leads to age-dependent changes in the maintenance of heart ventricle mitochondria

   bioRxiv·14 Oct 2026Preprint

1. MYO6 decreases GFAP in mice.

   “and an increase of the level of GFAP, the marker of glia cells, in adult mice.”

   Animalslack of myosin VIbrain

   Lack of unconventional myosin VI is associated with brain enlargement and gliosis progressing with age

   Acta neurobiologiae experimentalis·27 Dec 2025

More on GFAP

1. MYO6 protects against brain enlargement in mice.

   “Its lack leads to enlargement of the brain and its examined areas”

   Animalslack of myosin VIbrain

   Lack of unconventional myosin VI is associated with brain enlargement and gliosis progressing with age

   Acta neurobiologiae experimentalis·27 Dec 2025