Giornale Italiano Di Nefrologia · Aug 29, 2025
SGLT2i: Exploring Multiple Pathways in Cardiorenal Protection. Insights Into Nutrient Deprivation
By Mazza F, Apponi F, Cicciarelli A et al.
SGLT-2 inhibitors are a relatively new class of antidiabetic drugs. They activate a transcriptional response similar to calorie restriction characterized by the up-regulation of sensors involved in nutrient deprivation, such as SIRT1 and AMPK, and the down-regulation of mTOR, a molecule involved in nutritional excess signaling. The purpose of this review is to illustrate the main pathways of nutrient deprivation: a complex mechanistic framework partly responsible for the cardio-renal benefits that makes these drugs unique.