Zenodo · Apr 28, 2026
Autophagy enhancement via metformin-rapamycin combination for Z-AAT clearance
By Engine MAD
Low-dose metformin activates AMPK/ULK1 pathway while micro-dose rapamycin inhibits mTORC1, synergistically enhancing autophagosome formation and clearance of aggregated Z-variant SERPINA1 through LC3B-II and SQSTM1/p62-mediated selective autophagy