Berberine

Intervention1 paper7 findingsPubChem 2353ChEBI 16118

Reviews link berberine to extended lifespan, reduced chronic inflammation, decreased oxidative stress, and lower senescence-associated secretory phenotype expression. They also describe its activation of autophagy and AMPK signalling alongside inhibition of NF-κB signalling.

Outcomes

Senescence-associated secretory phenotype (SASP)

downin reviews1

1 study

Berberine decreases senescence-associated secretory phenotype (SASP).
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026

Senescence-associated secretory phenotype (SASP) →

NF-κB signalling

downin reviews1

1 study

Berberine inhibits NF-κB signalling.
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026

NF-κB signalling →

Autophagy

upin reviews1

1 study

Berberine activates autophagy.
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026

Autophagy →

AMPK signalling

upin reviews1

1 study

Berberine activates AMPK signalling.
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026

AMPK signalling →

Chronic inflammation

downin reviews1

1 study

Berberine decreases chronic inflammation.
Review
Berberine induces pleiotropic beneficial effects via hormesis · Pharmacological research · 25 Sep 2026

Chronic inflammation →

Oxidative stress and ROS signalling

downin reviews1

1 study

Berberine decreases oxidative stress and ROS signalling.
Review
Berberine induces pleiotropic beneficial effects via hormesis · Pharmacological research · 25 Sep 2026

Oxidative stress and ROS signalling →

Lifespan

upin reviews1

1 study

Berberine extends lifespan.
Review
Berberine induces pleiotropic beneficial effects via hormesis · Pharmacological research · 25 Sep 2026

Latest

Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP

ReviewFitoterapia29 Sep

Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential

ReviewReproductive medicine and biology28 Sep

Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1

CellsBiomedicines26 Sep

Berberine induces pleiotropic beneficial effects via hormesis

ReviewPharmacological research26 Sep