Diet

1. Diet has no effect on visceral fat area in humans.

   “Neither primary outcome differed between groups.”

   Human trial4 weeks

   Optimized Nutri-Dense meals versus a low-carbohydrate high-fat diet: an exploratory randomized controlled trial · Scientific reports · 3 Oct 2026

1. Diet decreases LDL cholesterol in humans.

   “LDL-cholesterol decreased in both Opti and LCHF Opti groups versus control”

   Human trial4 weeks

   Optimized Nutri-Dense meals versus a low-carbohydrate high-fat diet: an exploratory randomized controlled trial · Scientific reports · 3 Oct 2026

LDL cholesterol →

1. Diet has no effect on epigenetic regulation of gene expression in humans.

   Humanswithin-twin-pair and longitudinal analyses

   Dietary benefits on epigenetic aging may largely reflect familial factors · GeroScience · 26 Sep 2026

Epigenetic regulation of gene expression →

1. Diet protects against inflammation in humans.

   Review

   The Mediterranean-style Japanese Diet: A Systematic Review of the Recommendations for an Anti-aging Lifestyle · Endocrine, metabolic & immune disorders drug targets · 25 Sep 2026

Inflammation →

1. Diet increases mortality in humans (>300,000 deaths, ~8 million DALYs).

   Humans

   Dietary Risks and Cardiometabolic Disease Burden Across the United States: Geographic Inequalities, Age-Period-Cohort Patterns, and Projections to 2045 · American journal of preventive cardiology · 7 Aug 2026

1. Diet lowers the risk of cardiovascular disease in humans.

   “Evidence from randomized trials supports cardiovascular risk-factor and event reduction with selected dietary and exercise interventions (i.e., Mediterranean and Dietary Approaches to Stop Hypertension (DASH))”

   Review

   Modifiable Lifestyle Factors in Cardiovascular Disease Prevention: Current Evidence and Future Directions · Nutrients · 21 Sep 2026

2. Diet is associated with cardiovascular disease in humans.

   Humansin the United States

   Dietary Risks and Cardiometabolic Disease Burden Across the United States: Geographic Inequalities, Age-Period-Cohort Patterns, and Projections to 2045 · American journal of preventive cardiology · 7 Aug 2026

Cardiovascular disease →

1. Diet lowers the risk of cardiovascular disease mortality in silico (approximately 23,575 annual CVD deaths averted).

   “Under the specified counterfactual scenario, by matching Henan's dietary pattern to that of coastal Zhejiang, it was estimated that approximately 23,575 annual CVD deaths could be averted.”

   In silicocounterfactual Jiangnan dietary pattern matching coastal Zhejiang

   SuboptimalDietaryPatterns and Estimated Cardiovascular Disease Mortality Burden in China: A Repeated Cross-Sectional Comparative Risk Assessment · Nutrients · 17 Sep 2026

2. Diet is associated with cardiovascular disease mortality in silico (52.5% (95% UI, 45.6-58.6) in 2024).

   “The estimated proportion of CVD mortality attributable to suboptimal dietary factors based on comparative risk assessment was 49.8% (95% UI, 40.8-57.4) in 2008, increased numerically to 55.3% (48.1-61.6) in 2022, and was 52.5% (45.6-58.6) in 2024.”

   In silico2008 to 2024

   SuboptimalDietaryPatterns and Estimated Cardiovascular Disease Mortality Burden in China: A Repeated Cross-Sectional Comparative Risk Assessment · Nutrients · 17 Sep 2026

1. Diet is associated with DunedinPACE in humans (3.1% lower pace of aging per 1 unit increase in index score).

   Humans

   Dietary benefits on epigenetic aging may largely reflect familial factors · GeroScience · 26 Sep 2026

DunedinPACE →

1. Diet is associated with GrimAge in humans (0.55-0.67 years lower PCGrimAge per 1 unit increase in index score).

   Humans

   Dietary benefits on epigenetic aging may largely reflect familial factors · GeroScience · 26 Sep 2026

GrimAge →

1. Diet raises the risk of body mass index in humans (OR= 3.1, p = 0.014).

   “Within the low-carbohydrate/high-fat pattern, high-GRS individuals had higher odds of increased BMI (OR= 3.1, p = 0.014).”

   Humanslow-carbohydrate/high-fat patternn = 398

   Interactions Between Genetic Risk and Macronutrient Intake on Obesity-Related Traits in Sri Lankan Adults · Nutrients · 9 Sep 2026

1. Diet is associated with chronic kidney disease in humans.

   Humansin the United States

   Dietary Risks and Cardiometabolic Disease Burden Across the United States: Geographic Inequalities, Age-Period-Cohort Patterns, and Projections to 2045 · American journal of preventive cardiology · 7 Aug 2026

Chronic kidney disease →