Cardiometabolic multimorbidity
Disease10 papers17 findings
- Humans10
Effects
3Cognitive impairment
no changein humans1OR 1.01
1 study
Cognitive impairment
no changein humans1OR 1.01
Cardiometabolic multimorbidity has no effect on cognitive impairment in humans (OR = 1.01, 95% CI 0.95 to 1.07).
“not with a common any-cognitive transition effect (OR = 1.01, 0.95 to 1.07; I 2 = 81.8%)”
Humansbeginning in the distribution-defined unimpaired staten = 266,127
Cardiometabolic multimorbidity and cognitive-functional transitions across international ageing cohorts · Frontiers in public health · 10 Sep 2026
Physical function
downin humans1
1 study
Physical function
downin humans1
Cardiometabolic multimorbidity impairs physical function in humans (β = 0.0960, 95% CI 0.0809 to 0.1111).
“functional worsening ( β = 0.0960, 0.0809 to 0.1111; I 2 = 41.8%)”
Humansn = 361,562
Cardiometabolic multimorbidity and cognitive-functional transitions across international ageing cohorts · Frontiers in public health · 10 Sep 2026
Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Cardiometabolic multimorbidity impairs cognitive function in humans (β = 0.0459, 95% CI 0.0243 to 0.0675).
“each additional CMM condition accumulated was associated with cognitive worsening ( β = 0.0459, 95% CI 0.0243 to 0.0675; I 2 = 74.3%)”
Humansn = 361,562
Cardiometabolic multimorbidity and cognitive-functional transitions across international ageing cohorts · Frontiers in public health · 10 Sep 2026
Upstream
2AIP-BRI
no changein humans1
1 study
AIP-BRI
no changein humans1
AIP-BRI has no effect on cardiometabolic multimorbidity in humans.
Humansin ELSAn = 2,422
Metabolic indices predict cardiometabolic multimorbidity · Research Square · 28 Sep 2026 · Preprint
Biochemical sarcopenia index
no changein humans1
1 study
Biochemical sarcopenia index
no changein humans1
Biochemical sarcopenia index has no effect on cardiometabolic multimorbidity in humans.
Humansafter full adjustmentmean 9.27-year follow-upn = 6,092
Combined associations of triglyceride-glucose index and biochemical sarcopenia index with cardiometabolic multimorbidity in middle-aged and older Chinese adults · Maturitas · 26 Sep 2026
Associations
12CTI-FI
upin humans1HR 1.342
1 study
CTI-FI
upin humans1HR 1.342
CTI-FI raises the risk of cardiometabolic multimorbidity in humans (HR 1.342, 95% CI 1.246–1.445).
Humans5.00 yearsn = 5,586
Combined frailty and metabolic index tracks multimorbidity risk · Cardiovascular diabetology · 3 Oct 2026
New-onset and persistent disability
upin humans1
1 study
New-onset and persistent disability
upin humans1
Cardiometabolic multimorbidity raises the risk of new-onset and persistent disability in humans.
Humans
Cardiometabolic disease and depression worsen daily disability · Scientific reports · 2 Oct 2026
Depression
upin humans1HR 1.474
1 study
Depression
upin humans1HR 1.474
Depression raises the risk of cardiometabolic multimorbidity in humans (HR 1.474, 95% CI 1.002-2.168).
Humans
Depression burden links to cardiometabolic multimorbidity · Journal of global health · 2 Oct 2026
Depressive symptoms
upin humans1HR 1.25
1 study
Depressive symptoms
upin humans1HR 1.25
Cardiometabolic multimorbidity raises the risk of depressive symptoms in humans (HR 1.25, 95% CI 1.05–1.49).
Humansadjusted for demographic characteristics, lifestyle factors, clinical variables, and laboratory biomarkers2011 through 2020n = 10,726
Cardiometabolic multimorbidity tied to depression in older adults · Research Square · 30 Sep 2026 · Preprint
Depressive symptoms
upin humans1HR 1.44
1 study
Depressive symptoms
upin humans1HR 1.44
Depressive symptoms raise the risk of cardiometabolic multimorbidity in humans (HR 1.44, 95% CI 1.14–1.82).
Humansin CHARLS cohortn = 8,952
High depressive symptoms link to cardiometabolic multimorbidity · Research Square · 30 Sep 2026 · Preprint
Integrated cardiometabolic risk score
upin humans1
1 study
Integrated cardiometabolic risk score
upin humans1
Integrated cardiometabolic risk score predicts cardiometabolic multimorbidity in humans.
Humans
Metabolic indices predict cardiometabolic multimorbidity · Research Square · 28 Sep 2026 · Preprint
TyG-WHtR
upin humans1HR 3.18
1 study
TyG-WHtR
upin humans1HR 3.18
TyG-WHtR raises the risk of cardiometabolic multimorbidity in humans (HR 3.18, 95% CI 2.70-3.74).
Humansin CHARLSn = 8,682
Metabolic indices predict cardiometabolic multimorbidity · Research Square · 28 Sep 2026 · Preprint
Triglyceride-glucose index
upin humans1
1 study
Triglyceride-glucose index
upin humans1
Triglyceride-glucose index raises the risk of cardiometabolic multimorbidity in humans (P < 0.001).
Humansprospective cohortmean 9.27-year follow-upn = 6,092
Combined associations of triglyceride-glucose index and biochemical sarcopenia index with cardiometabolic multimorbidity in middle-aged and older Chinese adults · Maturitas · 26 Sep 2026
Systemic immune-inflammation index
upin humans1
1 study
Systemic immune-inflammation index
upin humans1
Systemic immune-inflammation index is associated with cardiometabolic multimorbidity in humans.
Humansfully adjusted model
Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity · Brain, behavior, & immunity - health · 19 Sep 2026
Depression
upin humans1OR 1.25
1 study
Depression
upin humans1OR 1.25
Depression is associated with cardiometabolic multimorbidity in humans (OR = 1.25, 95% CI: 1.03-1.53).
Humans
Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity · Brain, behavior, & immunity - health · 19 Sep 2026
All 12Fewer
Anxiety
upin humans1OR 1.15
1 study
Anxiety
upin humans1OR 1.15
Anxiety is associated with cardiometabolic multimorbidity in humans (OR = 1.15, 95% CI: 1.00-1.28).
Humans
Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity · Brain, behavior, & immunity - health · 19 Sep 2026
Functional limitation
upin humans1OR 1.33
1 study
Functional limitation
upin humans1OR 1.33
Cardiometabolic multimorbidity raises the risk of functional limitation in humans (OR = 1.33, 95% CI 1.27 to 1.40).
“each additional baseline CMM condition was associated with any functional transition (OR = 1.33, 95% CI 1.27 to 1.40; I 2 = 64.9%)”
Humansbeginning in the distribution-defined unimpaired staten = 266,127
Cardiometabolic multimorbidity and cognitive-functional transitions across international ageing cohorts · Frontiers in public health · 10 Sep 2026
Latest
10Combined frailty and metabolic index tracks multimorbidity risk
Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic…Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity.
Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity
Cardiometabolic disease and depression worsen daily disability
A longitudinal study of 16,780 Chinese adults tracked from 2012 to 2020 linked both conditions to higher disability risk and lower recovery.A longitudinal study of 16,780 Chinese adults tracked from 2012 to 2020 linked both conditions to higher disability risk and lower recovery.
Depression burden links to cardiometabolic multimorbidity
Depression progression raised cardiometabolic multimorbidity risk across cohorts, with hazard ratios of 1.474 in China, 1.325 in the USA, and 1.456 in…Depression progression raised cardiometabolic multimorbidity risk across cohorts, with hazard ratios of 1.474 in China, 1.325 in the USA, and 1.456 in Europe.
Association Between Physical Function and Cognitive Function Among Older Adults With Cardiometabolic Multimorbidity: The Mediating Role of Physical Activity
Cardiometabolic multimorbidity tied to depression in older adults
Depressive symptoms occurred in 38.6% of adults with cardiometabolic multimorbidity versus 33.0% without it, yielding an adjusted hazard ratio of…Depressive symptoms occurred in 38.6% of adults with cardiometabolic multimorbidity versus 33.0% without it, yielding an adjusted hazard ratio of 1.25.
High depressive symptoms link to cardiometabolic multimorbidity
High-stable symptoms carried hazard ratios of 1.91 in Chinese adults and 1.59 in US adults for incident cardiometabolic multimorbidity compared with…High-stable symptoms carried hazard ratios of 1.91 in Chinese adults and 1.59 in US adults for incident cardiometabolic multimorbidity compared with low-stable symptoms.
Metabolic indices predict cardiometabolic multimorbidity
TyG-WHtR tracked incident cardiometabolic multimorbidity with a hazard ratio of 3.18 in a Chinese cohort and showed consistent performance alongside…TyG-WHtR tracked incident cardiometabolic multimorbidity with a hazard ratio of 3.18 in a Chinese cohort and showed consistent performance alongside ICMRS in English adults.