Plxdc2
GeneMus musculus1 paper1 findingMGI 1914698NCBI Gene 67448Taxon 10090
- Animals1
Effects
1Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
Plxdc2 increases cellular senescence in mice.
“Mechanistically, we demonstrate that PLXDC2 contributes to microglial senescence via the cGAS-STING pathway, and its silencing attenuates neuroinflammation and oxidative stress.”
Animalsvia cGAS-STING pathwaymicroglia
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1AnimalsCellular senescence
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice
Silencing the upregulated gene PLXDC2 via brain-penetrating nanoparticles suppressed cGAS-STING signaling, reduced iron accumulation, and protected dopaminergic neurons.