SIRT1
GeneHomo sapiens8 papers2 findingsHGNC 14929NCBI Gene 23411Taxon 9606
- Animals1
- Cells1
Effects
2Mitochondrial dysfunction
downin reviews1
1 study
Mitochondrial dysfunction
downin reviews1
SIRT1 protects against mitochondrial dysfunction.
“SIRT1 maintains mitochondrial function through three interconnected pathways: PGC-1α-driven mitochondria biogenesis, FOXO-dependent antioxidant defense, and mitophagic clearance of damaged organelles.”
Review
SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026
Cellular senescence
downin reviews1
1 study
Cellular senescence
downin reviews1
SIRT1 decreases cellular senescence.
“SIRT1 levels and activity fall with age, and this decline directly promotes senescence.”
Review
SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026
Latest
10The therapeutic potential of melatonin: Focus on the SIRT1 signaling pathway
ReviewMolecular biology reports
The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms
ReviewMini reviews in medicinal chemistry
Melatonin and Diabetic Nephropathy: From Mechanistic Pathways to Translational Opportunities in Clinical Management
ReviewCurrent medicinal chemistry
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
ReviewReproductive medicine and biology
Lactic Acid Bacteria-Fermented Natural Products: Mechanisms and Evidence for Ageing- and Stem-Cell-Related Outcomes
ReviewFoods (Basel, Switzerland)
Activating Sirt1 reduces aortic valve calcification in mice and human cells
The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.
International journal of molecular medicine · Yan F et al.