Review
Crataegus Species as a Source of Geroprotective Phytochemicals: Biological Activities, Molecular Mechanisms and Therapeutic Perspectives
Abstract · CC BY
Population aging has intensified the search for natural compounds capable of promoting healthy aging and preventing age-related diseases. Among medicinal plants, species of the genus Crataegus (hawthorn) have attracted increasing attention because of their rich phytochemical composition and broad spectrum of biological activities.
- Cellular senescence
- Chronic inflammation
- Mitochondrial dysfunction
- AMPK signalling
- NF-κB signalling
- NRF2–KEAP1 antioxidant response
- Oxidative stress and ROS signalling
- PI3K–AKT signalling
- Senescence-associated secretory phenotype (SASP)
- Sirtuin signalling
- mTOR signalling
- NFE2L2
The paper
Crataegus Species as a Source of Geroprotective Phytochemicals: Biological Activities, Molecular Mechanisms and Therapeutic Perspectives
Kydyrbayeva A, Shalakhmetova T, Smalinskiene A et al.
Life · 4 Sep 2026