Dasatinib + quercetin
InterventionSenolytics1 paper3 findingsPubChem 3062316PubChem 5280343ChEBI 16243
- Human trial1
Outcomes
3Cellular senescence
downin humans1
1 study
Cellular senescence
downin humans1
Dasatinib + quercetin decreases cellular senescence in humans.
Human trialfibrotic MASHliverdasatinib 100 mg per day plus quercetin 1,000 mg per daythree consecutive days per week over 3 weeks, repeated across three 7-week cycles
Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial · Nature metabolism · 1 Oct 2026
Metabolic dysfunction-associated steatohepatitis
downin humans1
1 study
Metabolic dysfunction-associated steatohepatitis
downin humans1
Dasatinib + quercetin decreases metabolic dysfunction-associated steatohepatitis in humans (-1.43 ± 1.22 versus -0.39 ± 0.77).
Human trialfibrotic MASHliverdasatinib 100 mg per day plus quercetin 1,000 mg per daythree consecutive days per week over 3 weeks, repeated across three 7-week cycles
Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial · Nature metabolism · 1 Oct 2026
Fibrotic metabolic dysfunction-associated steatohepatitis
downin humans1
1 study
Fibrotic metabolic dysfunction-associated steatohepatitis
downin humans1
Dasatinib + quercetin decreases fibrotic metabolic dysfunction-associated steatohepatitis in humans (47% versus 7%).
Human trialfibrotic MASHliverdasatinib 100 mg per day plus quercetin 1,000 mg per daythree consecutive days per week over 3 weeks, repeated across three 7-week cycles
Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial · Nature metabolism · 1 Oct 2026
Latest
1Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.
Nature metabolism · Koning M et al.