Dysbiosis
Hallmark of aging30 papers6 findings
Studies in mice and rats show that Gastrodia elata polysaccharides and baicalein decrease dysbiosis. In humans, reviews link dysbiosis to epilepsy and age-related cognitive decline, describe its induction by heavy metals, and associate it with proteostasis loss.
- Humans2
- Animals6
- Cells2
- In silico1
Interventions
3Gastrodia elata polysaccharides
downin mice1
1 study
Gastrodia elata polysaccharides
downin mice1
Gastrodia elata polysaccharides decrease dysbiosis in mice.
Animalsnatural agingintestine
Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice · Food science & nutrition · 30 Sep 2026
Baicalein
downin rats1
1 study
Baicalein
downin rats1
Baicalein decreases dysbiosis in rats.
“baicalein ameliorated the unloading-induced gut microbiota disorder through the diminished abundance of Proteobacteria and elevated abundance of Actinobacteria and Firmicutes”
Animalsunloading-induced30 mg·kg -1 ·day -14 weeks
Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats · Molecules (Basel, Switzerland) · 20 Sep 2026
Heavy metals
upin humans1
1 study
Heavy metals
upin humans1
Heavy metals induce dysbiosis in humans.
“Environmental toxicants capable of these direct and indirect effects have included heavy metals, pesticides, herbicides, polychlorinated biphenyl (PCB) congeners, and endocrine-disrupting chemicals.”
Reviewgut
The Oxidative Stress and Inflammatory Metabolic Pathways of Some Environmental Toxicants Inflicting Human Disorders · Toxics · 22 Aug 2026
Associations
3Loss of proteostasis
upin reviews1
1 study
Loss of proteostasis
upin reviews1
Dysbiosis is associated with loss of proteostasis.
Review
The microbiota-proteostasis axis: implications in neurodegenerative diseases · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
Epilepsy
upin humans1
1 study
Epilepsy
upin humans1
Dysbiosis is associated with epilepsy in humans.
“Growing evidence supports an association between gut dysbiosis and epilepsy, particularly drug-resistant epilepsy”
Review
Aging, the microbiota-gut-brain axis, and late-life epilepsy: a hypothesis-driven review · Frontiers in molecular neuroscience · 14 Sep 2026
Age-related cognitive decline
upin humans1
1 study
Age-related cognitive decline
upin humans1
Dysbiosis is associated with age-related cognitive decline in humans.
“connecting intestinal dysbiosis, dysfunction of the blood-brain barrier (BBB), neuroinflammation, and age-related cognitive decline.”
Review
Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health · Biomedicines · 2 Sep 2026
Latest
30Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
Food science & nutrition · Shi H et al.
Traditional Chinese medicine-derived natural products and formulations as pharmacological modulators of ageing-related pathways: mechanisms and therapeutic potential
Gut microbes from hearing loss patients trigger inner ear damage in young mice
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
Research Square · Liu Y et al.