ATP
Biomarker6 papers3 findings
- Animals2
- Model organisms1
- Cells2
Interventions
2Denl/af9 knockdown
upin flies1
1 study
Denl/af9 knockdown
upin flies1
Denl/af9 knockdown increases ATP in flies.
Model organismspan-neuronal suppressionheadmales
Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies · bioRxiv · 2 Oct 2026 · Preprint
Epoxomicin
downin human cells1
1 study
Epoxomicin
downin human cells1
Epoxomicin decreases ATP in human cells.
“Proteasome inhibition during storage depleted ATP and altered RBC morphology without immediate oxidative damage.”
Cellsduring storageerythrocyte
Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026
Upstream
1Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Cellular senescence decreases ATP in human cells.
“medium from senescent astrocytes failed to elicit this response and instead promoted hydrogen peroxide accumulation, ATP depletion and reduced cellular metabolic activity”
Cellsconditioned medium from senescent astrocytes applied to neuronsneuron
Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026
Latest
6Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
bioRxiv · Yeewa R et al.
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · Chen X et al.
Proteasome activity maintains red blood cell integrity during storage and restoration
Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells.
Antioxidants (Basel, Switzerland) · Peltier S et al.
Senescent human astrocytes impair neuronal mitochondrial function through released factors
Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.
Antioxidants (Basel, Switzerland) · Amorim P et al.