Leptin

1. Leptin decreases senescence-associated beta-galactosidase in pig cells.

   Cellsunder heat stressSertoli cellmales

   Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling · Journal of animal science · 26 Sep 2026

Senescence-associated beta-galactosidase →

1. Leptin activates autophagy in pig cells.

   Cellsunder heat stressSertoli cellmales

   Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling · Journal of animal science · 26 Sep 2026

Autophagy →

1. Leptin activates MAPK/ERK signalling in pig cells.

   Cellsunder heat stressSertoli cellmales

   Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling · Journal of animal science · 26 Sep 2026

MAPK/ERK signalling →

1. Leptin decreases genomic instability in pig cells.

   Cellsunder heat stressSertoli cellmales

   Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling · Journal of animal science · 26 Sep 2026

Genomic instability →

1. Leptin decreases cellular senescence in pig cells.

   Cellsunder heat stressSertoli cellmales

   Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling · Journal of animal science · 26 Sep 2026

Cellular senescence →