DNA damage
Biomarker1 paper1 findingMeSH D004249
- Model organisms1
Associations
1Cladonema pacificum
upin C. pacificum1
1 study
Cladonema pacificum
upin C. pacificum1
Cladonema pacificum is associated with DNA damage in C. pacificum.
Model organismsduring aging
Aging impairs blastema formation and tissue regeneration in Cladonema jellyfish · Aging cell · 1 Oct 2026
Latest
25Brain cells organize into distinct DNA repair niches during mouse aging
Spatial transcriptomics shows neuronal and vascular DNA damage responses correspond to distinct local cell neighborhoods in aging brains.
Aging impairs blastema formation and tissue regeneration in Cladonema jellyfish
Older jellyfish medusae exhibit cell loss, heightened DNA damage, and defective wound closure that limit complex tentacle regrowth.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.
Restoring HIRA chromatin maintenance improves aged mouse oocyte quality
Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs.