Ferroptosis
Pathway13 papers5 findingsGO 0097707
In human cells, SIRT1 overexpression inhibits ferroptosis during osteogenic induction. Reviews also link ferroptosis to mitochondrial dysfunction in foam cells, increased atherosclerosis, and chronic inflammation in humans, whilst describing its prevention by nobiletin.
- Humans1
- Animals3
- Model organisms1
Interventions
2SIRT1 overexpression
downin human cells1
1 study
SIRT1 overexpression
downin human cells1
SIRT1 overexpression inhibits ferroptosis in human cells.
Cellsosteogenic inductionpcDNA3.1-Sirt1 transfectionaortic valve interstitial cell
Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026
Nobiletin
downin reviews1
1 study
Nobiletin
downin reviews1
Nobiletin prevents ferroptosis.
“The focus is placed on its antioxidant, anti-inflammatory, neuroprotective, cardioprotective, and metabolic regulatory effects, as well as its capacity to enhance mitophagy, modulate circadian rhythms, and prevent ferroptosis.”
Review
Nobiletin as a Geroprotective Flavonoid: Mechanisms of Action, Therapeutic Potential, and Challenges of Bioavailability · Antioxidants (Basel, Switzerland) · 7 Sep 2026
Effects
1Atherosclerosis
upin reviews1
1 study
Atherosclerosis
upin reviews1
Ferroptosis increases atherosclerosis.
“oxidized lipids, cellular debris, and inflammatory signals accumulate, promoting secondary necrosis, necrotic core expansion, plaque non-resolution, and instability.”
Reviewwhen dying foam cells are not efficiently cleared
Mitochondrial Redox Failure Links Senescence-like Foam Cell Stress to Ferroptosis and Plaque Non-Resolution in Atherosclerosis · Antioxidants (Basel, Switzerland) · 25 Aug 2026
Associations
2Chronic inflammation
upin humans1
1 study
Chronic inflammation
upin humans1
Ferroptosis is associated with chronic inflammation in humans.
Review
Ferroptosis-Driven Inflammaging in Age-Associated Degenerative Disorders: Molecular Mechanisms and Therapeutic Potential of Natural Products · Ageing research reviews · 1 Oct 2026
Mitochondrial dysfunction
upin reviews1
1 study
Mitochondrial dysfunction
upin reviews1
Mitochondrial dysfunction is associated with ferroptosis.
“allowing lipid peroxide accumulation to shift senescence-like foam cells toward ferroptosis susceptibility and defective plaque resolution.”
Reviewfoam cell
Mitochondrial Redox Failure Links Senescence-like Foam Cell Stress to Ferroptosis and Plaque Non-Resolution in Atherosclerosis · Antioxidants (Basel, Switzerland) · 25 Aug 2026
Latest
13Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice
The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.
International immunopharmacology · Wang Y et al.
Ferro-aging: iron-lipid axis in systemic decline
Fruit flies provide an in vivo model to study ferroptosis and lifespan
Ferroptosis-inducing compounds shortened fly lifespan in a diet-dependent manner, while antioxidant treatment restored longevity and reversed iron-related changes in males.
Redox biology · Zhang L et al.
Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies
Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications
Reframing Alzheimer's Disease Through a Redox-Metabolic Framework
Lactate receptor activation reduces cellular senescence and protects vascular health in mice
Loss of the lactate receptor GPR81 drives arterial senescence and lipid accumulation, while pharmacological stimulation restores vascular homeostasis in progeroid mice.
bioRxiv · Wu Y et al.