MDL-800
Intervention1 paper4 findingsPubChem 134717374
One study finds that MDL-800 reduces cartilage damage and age-associated osteoarthritis risk in male mice, reduces basal DNA damage in cells, and inhibits oxidative stress-induced p38 MAPK signalling in human cells.
- Animals1
Outcomes
3DNA damage
downin cells1Very low certainty
1 study
DNA damage
downin cells1Very low certainty
MDL-800 decreases DNA damage in cells.
Cellsbasal
MDL-800-induced SIRT6 activation decreases age-associated osteoarthritis in mice · Arthritis & rheumatology (Hoboken, N.J.) · 22 Sep 2026
p38 MAPK signalling
downin human cells1Very low certainty
1 study
p38 MAPK signalling
downin human cells1Very low certainty
MDL-800 inhibits p38 MAPK signalling in human cells.
Cellsoxidative stress-induced
MDL-800-induced SIRT6 activation decreases age-associated osteoarthritis in mice · Arthritis & rheumatology (Hoboken, N.J.) · 22 Sep 2026
Cartilage damage
downin mice1Very low certainty
1 study
Cartilage damage
downin mice1Very low certainty
MDL-800 decreases cartilage damage in mice.
Animalscompared to controlscartilage6 monthsmales
MDL-800-induced SIRT6 activation decreases age-associated osteoarthritis in mice · Arthritis & rheumatology (Hoboken, N.J.) · 22 Sep 2026
Associations
1Osteoarthritis
downin mice1Very low certainty
1 study
Osteoarthritis
downin mice1Very low certainty
MDL-800 lowers the risk of osteoarthritis in mice.
Animalsage-associated osteoarthritisweekly intraperitoneal injections6 monthsmales
MDL-800-induced SIRT6 activation decreases age-associated osteoarthritis in mice · Arthritis & rheumatology (Hoboken, N.J.) · 22 Sep 2026