S100A6

3 papers2 findings

HGNC NCBI Gene Taxon

2 independent labs in 2 countries

Funders: Agricultural Research Service and 4 more

Animals3

Effects

1

DNA damage response

upin cells1

1 study

S100A6 induces DNA damage response in cells.
“S100A6 recruits CacyBP to facilitate the ubiquitination and degradation of PARP1, leading to DNA damage”
Cellsvia S100A6 and CacyBP
Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice
Nature communications6 Jun 2026

More on DNA damage response

Upstream

1

NCOA1

upin mice1

1 study

NCOA1 increases S100A6 in mice.
“SRC-1 significantly promoted the expression S100A6.”
Animals
A protective role of SRC-1 against aging associated cognitive decline
Aging27 Aug 2025

Latest

2 in 12 months

Nature Communications7 Jun

Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice

Experiments in miceInterventions

European Journal of Immunology12 Mar

Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota

Experiments in miceBlood and immune system

Aging29 Aug

A protective role of SRC-1 against aging associated cognitive decline

Experiments in miceMechanisms