Palbociclib

Intervention1 paper3 findingsPubChem 5330286ChEBI 85993MeSH C500026

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

1 lab in 1 country

Funders: California Institute for Regenerative Medicine and 2 more

  • Animals1

Outcomes

3

Physical function

upin mice1

1 study
  1. Palbociclib improves physical function in mice.

    Animalsin aged mice

    Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline · Nature aging · 20 Aug 2026

Frailty

downin mice1

1 study
  1. Palbociclib decreases frailty in mice.

    Animalsin aged mice

    Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline · Nature aging · 20 Aug 2026

DNA damage response

downin mice1

1 study
  1. Palbociclib decreases DNA damage response in mice.

    Animalsin aged miceliver

    Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline · Nature aging · 20 Aug 2026

DNA damage response →

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