Palbociclib
Intervention1 paper3 findingsPubChem 5330286ChEBI 85993MeSH C500026
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
Funders: California Institute for Regenerative Medicine and 2 more
- Animals1
Outcomes
3Physical function
upin mice1
1 study
Physical function
upin mice1
Palbociclib improves physical function in mice.
Animalsin aged mice
Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline · Nature aging · 20 Aug 2026
Frailty
downin mice1
1 study
Frailty
downin mice1
Palbociclib decreases frailty in mice.
Animalsin aged mice
Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline · Nature aging · 20 Aug 2026
DNA damage response
downin mice1
1 study
DNA damage response
downin mice1
Palbociclib decreases DNA damage response in mice.
Animalsin aged miceliver
Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline · Nature aging · 20 Aug 2026