Progeria
Disease4 papers1 findingMeSH D011371
- Animals1
- Cells3
Interventions
1Farnesylation amino acid targeted editing
downin human cells1
1 study
Farnesylation amino acid targeted editing
downin human cells1
Farnesylation amino acid targeted editing protects against progeria in human cells.
CellsmRNA conjugated with lipid nanoparticlesneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026
Latest
4Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
bioRxiv · Mungo C et al.
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
Nature communications · Kim DW et al.
Extracellular vesicles carrying two microRNAs reduce vascular aging markers in progeria cells
Vesicles from melatonin-treated stem cells targeted SRSF1 and SP1 to lower progerin and cellular prion protein in cell models.
Pharmacological research · Joo EY et al.
Lactate receptor activation reduces cellular senescence and protects vascular health in mice
Loss of the lactate receptor GPR81 drives arterial senescence and lipid accumulation, while pharmacological stimulation restores vascular homeostasis in progeroid mice.
bioRxiv · Wu Y et al.