DNA repair
Pathway9 papers2 findingsGO 0006281
- Animals1
- Model organisms1
- Cells4
Interventions
2Sleep
upin reviews1
1 study
Sleep
upin reviews1
Sleep activates DNA repair.
Reviewneuron
Sleep and circadian regulation of DNA repair and retrotransposons in neuronal genome stability and neurodegenerative disease mechanisms · Frontiers in neuroscience · 15 Sep 2026
Farnesylation amino acid targeted editing
upin human cells1
1 study
Farnesylation amino acid targeted editing
upin human cells1
Farnesylation amino acid targeted editing activates DNA repair in human cells.
CellsHGPS NMOsneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026
Latest
9Brain cells organize into distinct DNA repair niches during mouse aging
Spatial transcriptomics shows neuronal and vascular DNA damage responses correspond to distinct local cell neighborhoods in aging brains.
bioRxiv : the preprint server for biology · Koshboresh A et al.
Human lymph node fibroblasts show cellular aging features before rheumatoid arthritis onset
Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.
RMD open · Jiménez-Martínez M et al.
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
Nature communications · Kim DW et al.
Genomic Stress and DNA Repair During Macrophage Differentiation and Inflammatory Activation
Targeted metal modulation preserves retinal structure and vision in zebrafish
Telomir-Zn depleted labile iron, lowered oxidative stress, and improved visual behaviors and epigenetic marks in zebrafish and cultured human retinal cells.
International journal of molecular sciences · Angel I et al.
Loss of adenosine deaminase impairs DNA repair and triggers astrocyte senescence in ALS
Disrupted purine metabolism downstream of TDP43 dysfunction correlates with disease progression and drives cellular senescence in sporadic amyotrophic lateral sclerosis.
International journal of molecular sciences · Hall B et al.
MUTYH protects telomeres from chronic oxidative damage in cancer cells
Targeted base excision repair prevents telomere loss and mutations caused by oxidized guanine lesions without halting cell proliferation.
Biomolecules · De Rosa M et al.