AGTR2
Gene1 paper5 findingsHGNC 338MGI 87966NCBI Gene 186Taxon 9606
- Animals1
Effects
5Lifespan
upin mice1
1 study
Lifespan
upin mice1
AGTR2 extends lifespan in mice (5-month reduction in median lifespan (26 months for AT2R-KO vs. 31 months for WT)).
Animalsin AT2R knockout mice
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
NLRP3 inflammasome
downin mice1
1 study
NLRP3 inflammasome
downin mice1
AGTR2 inhibits NLRP3 inflammasome in mice.
Animalsin aged AT2R knockout mice
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
AGTR2 inhibits cellular senescence in mice.
Animalsin aged AT2R knockout mice
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Cardiac fibrosis
downin mice1
1 study
Cardiac fibrosis
downin mice1
AGTR2 protects against cardiac fibrosis in mice.
Animalsin aged AT2R knockout mice
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Heart function
downin mice1
1 study
Heart function
downin mice1
AGTR2 protects against heart function in mice.
Animalsin aged AT2R knockout mice
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Latest
1Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.