High-protein diet

1. High-protein diet improves grip strength in humans (MD: -1.8; d = 0.30; 95% CI: 0.15, 0.35).

   Human trialhypocaloric diet plus exercise in older males with prediabetes and obesity1.4 g protein/kg/d1.4 g/kg/d6 momales

   Influence of Protein Intake during Obesity Reduction on Physical Function and Body Habitus in Older Males with Prediabetes: A Pilot Study · Current developments in nutrition · 25 Jul 2026

Grip strength →

1. High-protein diet improves 6-minute walk distance in humans (MD: 29.0 m; d = 0.53; 95% CI: <0, 1.19).

   Human trialhypocaloric diet plus exercise in older males with prediabetes and obesity1.4 g protein/kg/d1.4 g/kg/d3 momales

   Influence of Protein Intake during Obesity Reduction on Physical Function and Body Habitus in Older Males with Prediabetes: A Pilot Study · Current developments in nutrition · 25 Jul 2026

6-minute walk distance →

1. High-protein diet improves Short Physical Performance Battery in humans (Cohen's d = 0.68 at 6 mo).

   Human trialhypocaloric diet plus exercise in older males with prediabetes and obesity1.4 g protein/kg/d1.4 g/kg/d6 momales

   Influence of Protein Intake during Obesity Reduction on Physical Function and Body Habitus in Older Males with Prediabetes: A Pilot Study · Current developments in nutrition · 25 Jul 2026

Short Physical Performance Battery →

1. High-protein diet raises the risk of skeletal muscle mass decline in humans (aHR 1.20, 95% CI 1.01-1.42).

   Humansversus normal dietmedian follow-up of 5.6 yearsn = 9,516

   Macronutrient-Based Dietary Patterns and the Risk of Muscle Mass Decline in Middle-Aged and Older Adults: A Prospective Community-Based Cohort Study · Metabolites · 11 Aug 2026