Metabolic and bariatric surgery

1. Metabolic and bariatric surgery decreases HbA1c in humans (WMD = -1.31%; 95% CI: -1.66 to .96).

   Reviewcompared with GLP-1 RA therapy

   The comparative effectiveness of bariatric operations versus GLP-1 RAs: a systematic review and meta-analysis · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 29 Jul 2026

HbA1c →

1. Metabolic and bariatric surgery induces metabolomic alterations in humans (224 metabolites).

   Humanspost-surgeryplasma12 monthsn = 115

   Temporal changes in circulating metabolites after metabolic and bariatric surgery and risk of incident coronary heart disease: evidence from prospective cohort and nested case-control studies · International journal of surgery (London, England) · 3 Jun 2026

Metabolomic alterations →

1. Metabolic and bariatric surgery lowers the risk of major adverse cardiovascular events in humans (RR = .59; 95% CI: .46-.77).

   Reviewcompared with GLP-1 RA therapy

   The comparative effectiveness of bariatric operations versus GLP-1 RAs: a systematic review and meta-analysis · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 29 Jul 2026

Major adverse cardiovascular events →

1. Metabolic and bariatric surgery lowers the risk of coronary heart disease in humans (37 metabolites).

   Humansnested case-control studyplasman = 1,194

   Temporal changes in circulating metabolites after metabolic and bariatric surgery and risk of incident coronary heart disease: evidence from prospective cohort and nested case-control studies · International journal of surgery (London, England) · 3 Jun 2026

Coronary heart disease →