GrimAge
Biomarker4 papers2 findings
- Humans4
Associations
2Major depressive disorder
upin humans1OR 1.44
1 study
Major depressive disorder
upin humans1OR 1.44
GrimAge is associated with Major depressive disorder in humans (OR = 1.44, 95% CI = 1.12 – 1.85).
Humans6 months after trauma6 monthsn = 660
Accelerated epigenetic aging predicts major depression and brain changes after trauma · medRxiv · 28 Sep 2026 · Preprint
Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Cognitive function is associated with GrimAge in humans (-3.16 ± 3.08 vs 0.00 ± 4.14 years; Cohen's d = -0.87).
Humansin Healthy Cognitive Agers aged ≥80 years maintaining MMSE = 30n = 80
Older adults with preserved cognition show slower biological aging and longer telomeres · Aging and disease · 23 Sep 2026
Latest
4Older adults with preserved cognition show slower biological aging and longer telomeres
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.
Aging and disease · Salech F et al.
Telomere attrition marks disease severity in chronic cholestatic liver diseases
Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.
Alimentary pharmacology & therapeutics · Alsakarneh SG et al.
Accelerated epigenetic aging predicts major depression and brain changes after trauma
Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35.
medRxiv · Navarro-Flores A et al.
Epigenetic age acceleration tracks lower baseline cognition and greater retest gains
In middle-aged adults, biological aging correlated with processing speed variability and baseline performance but did not predict cognitive change over time.
The journals of gerontology. Series A, Biological sciences and medical sciences · Zavala DV et al.