Gene expression
Biomarker1 paper1 finding
- Animals1
Associations
1Sleep deprivation
mixedin mice1Very low certainty
1 study
Sleep deprivation
mixedin mice1Very low certainty
Sleep deprivation is associated with gene expression in mice.
Animalstransient sleep deprivation
Stress and recovery dynamics reveal transcriptomic stability limits across aging mouse organs · bioRxiv · 30 Sep 2026 · Preprint
Latest
45Biological aging and heart health link to lung disease risk
A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory…A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases.
A 5:2 fasting regimen curbs muscle impairment in mice
Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without…Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without altering cumulative energy intake.
REST in the Central Nervous System: Context-Dependent Regulation of Neuronal Homeostasis and Disease
Membrane attack complex deposits on pericytes in human eyes
Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle…Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle cells, and macrophages.
Simulated microgravity raises transcriptomic age in organoids
Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher…Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher transcriptomic-age estimates in brain and heart models.
SATB1 loss reshapes 3D genome in mouse naive T cells
Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene…Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.
ApoD drives cellular aging phenotypes through a nuclear mechanotransduction feedback loop
In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular…In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular polarity.