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Smoking

Intervention2 papers3 findings

  • Humans2

Associations

3

ASXL1 mutation

upin humans1

1 study
  1. Smoking is associated with ASXL1 mutation in humans.

    Humans

    Clonal blood mutations in ASXL1 associate with higher lung cancer risk · Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 28 Sep 2026

ASXL1 mutation →

Relative leukocyte telomere length

downin humans1

1 study
  1. Smoking is associated with relative leukocyte telomere length in humans (adjusted conditional-median ratio 0.38, 95% bootstrap CI 0.22-0.67).

    Humansin asthma, median-regression modellight smoking (1-4 cigarettes/day)leukocyte1-4 cigarettes/daymalesn = 148

    Associations of light smoking with serum carcinoembryonic antigen and relative leukocyte telomere length in men with asthma · Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace · 23 Sep 2026

Relative leukocyte telomere length →

Carcinoembryonic antigen

upin humans1

1 study
  1. Smoking is associated with carcinoembryonic antigen in humans (adjusted ratio 1.18, 95% CI 1.01-1.38).

    Humansin asthma, age-adjusted modellight smoking (1-4 cigarettes/day)serum1-4 cigarettes/daymalesn = 150

    Associations of light smoking with serum carcinoembryonic antigen and relative leukocyte telomere length in men with asthma · Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace · 23 Sep 2026

Carcinoembryonic antigen →

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HumansPeer-reviewed

Clonal blood mutations in ASXL1 associate with higher lung cancer risk

Researchers analyzing two large human cohorts found that ASXL1-mutant clonal hematopoiesis linked to more than triple the risk of lung cancer in smokers.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · Zhang Z et al.

Paper