Partial reprogramming

1. OSKM improves liver regeneration.

   Animalsafter acetaminophen-induced injurylipid nanoparticle mRNA

   RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026

1. OSKM induces Sox9+ LPLC-like cells.

   Animalslipid nanoparticle mRNA

   RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026

Sox9+ LPLC-like cells →

1. OSKM induces hepatocyte dedifferentiation.

   Animalslipid nanoparticle mRNA

   RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026

1. OSKM induces liver progenitor-like cells.

   Animalswithout injury

   RNA delivery linked to enhanced liver regeneration in mice · Cell reports. Medicine · 1 Oct 2026

1. Transient reprogramming decreases myeloid bias in mice.

   Animalsphysiological and LPS-driven HSC aging

   Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress · bioRxiv · 31 Aug 2026 · Preprint

1. Transient reprogramming improves hematopoietic reconstitution in mice.

   Animalsphysiological and LPS-driven HSC aging

   Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress · bioRxiv · 31 Aug 2026 · Preprint

1. Partial reprogramming improves stem cell differentiation in mouse cells.

   “Partial reprogramming of old neural stem cells in culture improves transcriptomic signatures of aging and boosts neuroblast and neuron production during differentiation”

   Cellsin cultured old neural stem cells during differentiationneural stem cell

   PARTIAL REPROGRAMMING OF THE AGING NEUROGENIC NICHE · GSA 2024 abstract · 31 Dec 2024

Stem cell differentiation →

1. Partial reprogramming increases neural stem cell in mice.

   “partial reprogramming in the SVZ neurogenic niche itself increases the proportion of neuroblasts and neural stem cells in old mice.”

   Animalsin the SVZ neurogenic niche itself in old micesubventricular zone

   PARTIAL REPROGRAMMING OF THE AGING NEUROGENIC NICHE · GSA 2024 abstract · 31 Dec 2024

1. Partial reprogramming increases neuroblast in mice.

   “partial reprogramming of the whole body in old mice restores the proportion of neuroblasts - cells committed to give rise to new neurons - in the neurogenic niche.”

   Animalsin old micesubventricular zone

   PARTIAL REPROGRAMMING OF THE AGING NEUROGENIC NICHE · GSA 2024 abstract · 31 Dec 2024

1. Partial reprogramming improves youthful gene expression in human cells.

   “TF combinations were more likely than individual factors to reverse cell age, and many of these effects persisted after TF activation ceased.”

   CellsTF combinations compared to individual factors in aged human T cellsT cell

   PARTIAL REPROGRAMMING REVERSES FEATURES OF AGING IN HUMAN T LYMPHOCYTES · GSA 2024 abstract · 31 Dec 2024

1. Partial reprogramming is associated with DNA methylation in silico (14 CpG sites).

   In silicon = 189

   Conserved Partial Reprogramming Effects on the Methylome · Epigenomes · 13 Aug 2026

DNA methylation →