MALDI-TOF imaging mass spectrometry demonstrates sex- and age-dependent spatial changes in brain energy metabolism in response to amyloid stress using a mouse model of Alzheimers Disease

Abstract

Alzheimer's disease (AD) is the most common form of dementia, and no therapies currently exist that prevent or slow its progression. Lactate has recently emerged as both an energy substrate and a signaling molecule required for memory formation, acting in part through a novel epigenetic mechanism termed histone lactylation.