In women undergoing limb immobilization, prehabilitation increased quadriceps area by 6.7% before disuse, preserving more post-immobilization muscle…In women undergoing limb immobilization, prehabilitation increased quadriceps area by 6.7% before disuse, preserving more post-immobilization muscle despite identical 3.2% relative losses.
In a randomized trial of 36 older stroke patients, a two-week combined regimen reduced reaction time more than either therapy alone.In a randomized trial of 36 older stroke patients, a two-week combined regimen reduced reaction time more than either therapy alone. In a randomized controlled trial of 36 older patients with stroke of 6 to 12 months' duration, researchers tested the effects of moderate-intensity aerobic…
Adding a GLP-1 receptor agonist was linked to lower rates of major adverse kidney events (HR 0.70) compared with SGLT2 inhibitor monotherapy over 12…Adding a GLP-1 receptor agonist was linked to lower rates of major adverse kidney events (HR 0.70) compared with SGLT2 inhibitor monotherapy over 12 months. In adults with chronic kidney disease, researchers evaluated whether adding a glucagon-like peptide-1 receptor agonist (GLP-1RA) to…
In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone…In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone mineral density. In ovariectomized mice, researchers tested whether pH-responsive ZIF-90 nanoparticles loaded with puerarin could mitigate bone…
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells. In ApoE-deficient mice fed a high-fat diet and in cultured vascular smooth muscle cells, researchers examined how salvianolic acid A influences…
A specialized encapsulation system slows protein digestion to boost muscle signaling and physical endurance in a murine sarcopenia model.A specialized encapsulation system slows protein digestion to boost muscle signaling and physical endurance in a murine sarcopenia model. In a murine model of sarcopenia, researchers tested whether slowing the release of whey protein isolate could improve muscle mass and physical function.
In mouse models, alternate-day fasting stimulated hepatocyte nitric oxide production to suppress stellate cell activation, an effect abolished by…In mouse models, alternate-day fasting stimulated hepatocyte nitric oxide production to suppress stellate cell activation, an effect abolished by hepatocyte eNOS deletion. In mouse models and human fibrotic liver samples, researchers found that eNOS expression was markedly suppressed…
Growth hormone treatment rescues germline redox balance and sperm quality in aged males through a Grtp1-dependent mechanism.Growth hormone treatment rescues germline redox balance and sperm quality in aged males through a Grtp1-dependent mechanism. In an animal study of reproductive aging, researchers used single-cell transcriptomics and cross-sex comparisons to identify Grtp1 as a key protector of male…
The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis. In ovariectomized rats, researchers tested an engineered nanodelivery system designed to deliver betaine directly to bone tissue.
Cinaciguat reversed endothelial defenestration and restored paracrine signaling that enables rat hepatocytes to clear circulating lipids and…Cinaciguat reversed endothelial defenestration and restored paracrine signaling that enables rat hepatocytes to clear circulating lipids and amyloid-beta. In aged rats, treating animals with the soluble guanylate cyclase activator cinaciguat for two weeks restored liver sinusoidal…
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat…Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts. In male C57BL/6 mice and rat cardiomyoblasts, researchers examined how environmental arsenic promotes cardiac aging and whether…
Estimated VO2peak rose from 19.3 to 22.0 mL.min-1.kg-1 with high-intensity training compared with a slight drop from 19.9 to 19.7 in standard…Estimated VO2peak rose from 19.3 to 22.0 mL.min-1.kg-1 with high-intensity training compared with a slight drop from 19.9 to 19.7 in standard recommendations. In 103 adults with type 2 diabetes and rapid renal function decline, a two-year randomized controlled trial evaluated the effects…
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes. In naturally aged mice and D-galactose-induced senescent H9c2 cells, Astragaloside IV mitigated cardiac aging and improved heart function.
Oral treatment restored bone density and mechanical strength while suppressing inflammatory markers and rebalancing intestinal bacteria in a disuse…Oral treatment restored bone density and mechanical strength while suppressing inflammatory markers and rebalancing intestinal bacteria in a disuse model. In a hind limb unloading rat model simulating disuse, researchers administered baicalein by gavage at 30 mg per kilogram daily for four…
