Interventions

Sun 27 Sep4 papers

bioRxivAnimalsPreprint

Caloric restriction dynamically alters RNA splicing and lipid composition in mouse brains

Researchers found that dietary restriction reshapes alternative splicing in an age-specific manner while driving coordinated changes in cortical brain…Researchers found that dietary restriction reshapes alternative splicing in an age-specific manner while driving coordinated changes in cortical brain lipids. In a new preprint, researchers analyzed brain tissue from mice subjected to caloric restriction across adulthood to examine gene…

A mouse brain section above a mouse, full and sparse food bowls, dense against sparse brain tissue, straight against kinked lipids, and RNA chains.
Dietary restriction

Sat 26 Sep97 papers

bioRxivAnimalsPreprint

Lactate receptor activation reduces arterial senescence in mice

In progeroid mice, activating the GPR81 receptor with the agonist CHBA reduced arterial lipid buildup, lowered cellular senescence, and improved…In progeroid mice, activating the GPR81 receptor with the agonist CHBA reduced arterial lipid buildup, lowered cellular senescence, and improved endothelial integrity. In human aortic transcriptomic data, expression of the lactate receptor gene HCAR1 declined significantly with age.

Two mice stand above a vessel wall, contrasting degraded, vacuolated tissue on the left with healthy, organised layers of elastic fibres on the right.
BiomoleculesAnimals

Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy

The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway.The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway. In a study using six-month-old female ovariectomized rats, researchers tested whether nuciferine protects against bone loss caused by estrogen…

Effects of Nue on bone microarchitecture, serum biomarkers, and tissue histology in OVX rats.
Osteopenia
AntioxidantsModel organisms

Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes

The treatment relies on SKN-1 activation to increase collagen synthesis and enhance healthspan markers in Caenorhabditis elegans.The treatment relies on SKN-1 activation to increase collagen synthesis and enhance healthspan markers in Caenorhabditis elegans. In the nematode Caenorhabditis elegans, researchers investigated whether the antipsychotic drug pimozide could extend lifespan and improve healthspan.

Pimozide prolongs the lifespan of C. elegans.
BiogerontologyAnimals

Erigeron breviscapus extends lifespan in worms

Treatment prolonged average lifespan up to a maximum of 18.68% while enhancing stress resistance and motor function in the roundworms.Treatment prolonged average lifespan up to a maximum of 18.68% while enhancing stress resistance and motor function in the roundworms. In roundworms (Caenorhabditis elegans) and SAMP8 mice, researchers tested the anti-senescence effects of the herbal medicine Erigeron breviscapus…

Figure 1
Kidney
Frontiers in AgingHuman trial

Lifestyle modification reduces phenotypic age in adults with prediabetes

A six-month randomized trial in Arab adults found structured diet and exercise reduced biological age alongside metabolic markers.A six-month randomized trial in Arab adults found structured diet and exercise reduced biological age alongside metabolic markers. In a randomized clinical trial of 181 Arab adults with prediabetes, researchers tested whether a structured lifestyle modification program affects biological…

Figure 1
Prediabetes
Nature AgingAnimals

Oral bacterium shifts aged mouse profiles toward younger states

Supplementing aged mice with heat-killed Neisseria flavescens restored their serum metabolome, liver transcriptome and gut microbiome toward younger…Supplementing aged mice with heat-killed Neisseria flavescens restored their serum metabolome, liver transcriptome and gut microbiome toward younger states. Analyzing human multi-modality data, researchers identified the oral commensal bacterium Neisseria flavescens as associated with…

A dark, mottled liver above a mouse, beside a reddish liver above a mouse facing paired bacterial cells.
Signal Transduction and Targeted TherapyAnimals

Inotodiol preserves muscle mass and function in aged mice

The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline. In aged mice, treatment with the mycosterol inotodiol significantly improved muscle mass and function.

Muscle aging is associated with metabolic disturbances, mitochondrial dysfunction, and a decrease in the activity of the SIRT3/PGC-1α pathway.
Sarcopenia