Six weeks of blood flow restricted resistance exercise enlarged muscle progenitor cells and shifted fibro-adipogenic progenitors toward a pro-myogenic…Six weeks of blood flow restricted resistance exercise enlarged muscle progenitor cells and shifted fibro-adipogenic progenitors toward a pro-myogenic state in healthy older adults.
Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells…Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain. In aged mice and mouse models of Alzheimer's disease, researchers tested CAR T cell therapies targeting inflammatory…
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung…The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease. In a preprint evaluating mice and human lung cells, researchers found that rapamycin alleviates pulmonary fibrosis by suppressing…
The peptide suppressed inflammation and microglial senescence in mouse models, acting through an autophagy-related signaling pathway.The peptide suppressed inflammation and microglial senescence in mouse models, acting through an autophagy-related signaling pathway. In older and D-galactose-induced mouse models, ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation.
In patients with diabetes and kidney disease, SGLT2 inhibitors carried an infection hazard ratio of 0.99 for UTIs and 1.31 for genital infections…In patients with diabetes and kidney disease, SGLT2 inhibitors carried an infection hazard ratio of 0.99 for UTIs and 1.31 for genital infections versus DPP-4 inhibitors. In a nationwide cohort of 41,801 South Korean adults with type 2 diabetes and chronic kidney disease, researchers…
Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher…Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses. In aged mice and non-human primates, a newly designed bispecific T-cell engager safely eliminated senescent cells and improved…
In 53 older men and 48 older women, 28 days of fasting lowered maximal expiratory pressure in men while shifting plasma neuromuscular markers in both…In 53 older men and 48 older women, 28 days of fasting lowered maximal expiratory pressure in men while shifting plasma neuromuscular markers in both sexes. In a study of 53 older men and 48 older women observing Ramadan, researchers tracked markers of respiratory sarcopenia alongside…
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age. In humans, mice, and pigs, aged placentas exhibit increased macrophage CD38 expression and NAD+ deficiency.
In a six-week trial of 40 older adults, four-channel stimulation improved hyoid movement, swallowing safety, and oral intake more than two-channel…In a six-week trial of 40 older adults, four-channel stimulation improved hyoid movement, swallowing safety, and oral intake more than two-channel therapy. In a randomized controlled trial, researchers evaluated sequential four-channel neuromuscular electrical stimulation in 40 older…
In ApoE-deficient mice fed for six months, mild food restriction reduced weight gain by 5% but increased circulating cholesterol and accelerated…In ApoE-deficient mice fed for six months, mild food restriction reduced weight gain by 5% but increased circulating cholesterol and accelerated plaque formation. In ApoE-deficient mice, mild food restriction designed to reduce body-weight gain by 5% accelerated atherosclerosis over a…
Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference.Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference. In a randomized clinical trial of 703 older adults with coexisting mild cognitive impairment and moderate to severe hearing loss, hearing aids did…
The combined regimen lowered TMAO accumulation and suppressed inflammatory signaling more effectively than cognitive training alone.The combined regimen lowered TMAO accumulation and suppressed inflammatory signaling more effectively than cognitive training alone. In 18-month-old male Sprague-Dawley rats with D-galactose-induced aging, researchers tested whether combining cognitive and motor training outperforms…
Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68).Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68). In a multicenter study of 164,918 adults with hypertension, researchers evaluated whether renin-angiotensin system inhibitors (RASIs) reduced dementia…
The engineered dressing scavenges reactive oxygen species, shifts immune cells toward repair, and promotes blood vessel formation to improve tissue…The engineered dressing scavenges reactive oxygen species, shifts immune cells toward repair, and promotes blood vessel formation to improve tissue regeneration in senescent skin.
