Kidney
Body system113 papersUBERON 0001008
- Human trial5
- Humans64
- Animals5
- Model organisms1
- Cells2
- In silico7
Latest
113TMEM174 deficiency shortens lifespan and stiffens vessels in mice
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality.
Renal Function, Appendicular Lean Mass, and Bone Stiffness: Indirect Associations Through Fibroblast Growth Factor 21
NMR metabolomics improves prediction of cardiometabolic diseases
In 54,933 healthcare system participants, profiling 250 NMR biomarkers enhanced standard risk prediction for type 2 diabetes, kidney disease, and…In 54,933 healthcare system participants, profiling 250 NMR biomarkers enhanced standard risk prediction for type 2 diabetes, kidney disease, and liver disease.
Diverse diet protects kidneys while carb restriction raises risk
Genetically predicted unrestricted eating reduced renal failure risk (odds ratio 0.1269), while avoiding sugar and wheat increased susceptibility.Genetically predicted unrestricted eating reduced renal failure risk (odds ratio 0.1269), while avoiding sugar and wheat increased susceptibility.
Facial foundation model estimates clinical biomarkers
Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across…Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across four cohorts.
Semaglutide may protect kidneys by reducing vascular resistance
In a 52-week trial of 106 people with type 2 diabetes and chronic kidney disease, semaglutide reduced renal vascular resistance without altering…In a 52-week trial of 106 people with type 2 diabetes and chronic kidney disease, semaglutide reduced renal vascular resistance without altering coprimary imaging endpoints.
Frailty and dementia link to poorer outcomes after cystectomy
In 3,600 older Medicare beneficiaries with bladder cancer, baseline frailty and dementia were associated with more care transitions and facility…In 3,600 older Medicare beneficiaries with bladder cancer, baseline frailty and dementia were associated with more care transitions and facility admissions after surgery.
Plasma p-tau217 yields discordant Alzheimer results in 8.5% of adults
False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and…False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and clinical stage.