Physical activity
Intervention11 papers9 findings
- Human trial1
- Humans10
Outcomes
1Atherosclerotic cardiovascular disease
downin humans1
1 study
Atherosclerotic cardiovascular disease
downin humans1
Physical activity protects against atherosclerotic cardiovascular disease in humans.
Humans13 yearsn = 468,266
Risk factors for atherosclerosis diverge across vascular beds · American journal of preventive cardiology · 19 Jun 2026
Associations
8Cognitive frailty
mixedin humans1
1 study
Cognitive frailty
mixedin humans1
Physical activity is associated with cognitive frailty in humans.
Humansrural older adults
Early cognitive frailty is reversible in rural older adults · BMC geriatrics · 3 Oct 2026
Metabolic syndrome
downin humans1OR 0.44
1 study
Metabolic syndrome
downin humans1OR 0.44
Physical activity lowers the risk of metabolic syndrome in humans (OR = 0.44 per 0.1-unit increase; 95% CI: 0.28-0.68).
Humansin women receiving adjuvant endocrine therapy for breast cancerfemalesn = 150
Mediterranean Diet, Physical Activity, and Metabolic Syndrome in Breast Cancer Survivors on Adjuvant Endocrine Therapy: A Cross-Sectional Study From North Africa · Journal of the American Nutrition Association · 3 Oct 2026
Mortality
mixedin humans1
1 study
Mortality
mixedin humans1
Physical activity is associated with mortality in humans.
Humanscovariate adjustment strategies
Covariate Selection in Physical Activity Epidemiology: Too Little, Too Much, or Just Right? · Journal of physical activity & health · 2 Oct 2026
Type 2 diabetes
mixedin humans1
1 study
Type 2 diabetes
mixedin humans1
Physical activity is associated with type 2 diabetes in humans.
Humanscovariate adjustment strategies
Covariate Selection in Physical Activity Epidemiology: Too Little, Too Much, or Just Right? · Journal of physical activity & health · 2 Oct 2026
Hypertension
mixedin humans1
1 study
Hypertension
mixedin humans1
Physical activity is associated with hypertension in humans.
Humanscovariate adjustment strategies
Covariate Selection in Physical Activity Epidemiology: Too Little, Too Much, or Just Right? · Journal of physical activity & health · 2 Oct 2026
Cardiorespiratory fitness
upin humans1
1 study
Cardiorespiratory fitness
upin humans1
Physical activity is associated with cardiorespiratory fitness in humans (9 of 16 outcomes).
Humans65.7% womensn = 67
A reproducible pipeline for processing commercial wearable step-count data in aging cohorts: Application and evaluation in the STRRIDE-PD reunion study · Experimental gerontology · 24 Sep 2026
Depression
downin humans1−54% lower risk for five types
1 study
Depression
downin humans1−54% lower risk for five types
Physical activity lowers the risk of depression in humans (54% lower risk for five types).
Humansgeneral population free of depression at baselinemedian follow-up of 10.01 yearsn = 160,358
Physical Activity and Risk of Depression: Does the Type, Frequency and Number of Activities Matter? UK Biobank Prospective Cohort Study · Mayo Clinic proceedings · 24 Sep 2026
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
Physical activity is associated with cognitive function in humans.
“physical activity displayed the broadest pattern of independent associations, encompassing global cognition, visual attention and processing speed, executive function, processing speed, and selective attention and concentration.”
Humansin older adults with mild cognitive impairment
Associations of Social Support, Loneliness, and Physical Activity with Cognitive Function in Older Adults with Mild Cognitive Impairment · Journal of clinical medicine · 17 Sep 2026
Latest
11Early cognitive frailty is reversible in rural older adults
In older adults with reversible cognitive frailty, recovery intensity to cognitive impairment alone was 0.429 versus 0.224 for deterioration to…In older adults with reversible cognitive frailty, recovery intensity to cognitive impairment alone was 0.429 versus 0.224 for deterioration to potentially reversible cognitive frailty.
Risk factors for atherosclerosis diverge across vascular beds
Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent…Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent polyvascular spread and mortality.
Mediterranean Diet, Physical Activity, and Metabolic Syndrome in Breast Cancer Survivors on Adjuvant Endocrine Therapy: A Cross-Sectional Study From North Africa
Covariate Selection in Physical Activity Epidemiology: Too Little, Too Much, or Just Right?
Physical inactivity links to cognitive impairment up to age 90
Being sedentary was linked to cognitive impairment between ages 78–85 (odds ratio 2.61) and ages 85–90 (odds ratio 2.90) in older adults.Being sedentary was linked to cognitive impairment between ages 78–85 (odds ratio 2.61) and ages 85–90 (odds ratio 2.90) in older adults.