Human trial

γδ T-cell interferon-γ production reflects metabolic improvement during SGLT2 inhibitor-based therapy in type 2 diabetes

Frontiers in Endocrinology

Abstract

Introduction Chronic low-grade meta-inflammation contributes to insulin resistance and metabolic dysfunction in type 2 diabetes (T2D). γδ T cells have emerged as important mediators of metabolic inflammation, yet their responsiveness to metabolic improvement in humans remains poorly understood.

The paper

Special Hospital for Medical Rehabilitation of the Heart and Lung Diseases and Rheumatism Thalassotherapia Opatija · University of Rijeka

Frontiers in Endocrinology · 11 Sep 2026 · CC BY

doi.org/10.3389/fendo.2026.1922668PubMed 42798540