Chronic obstructive pulmonary disease
Disease3 papers5 findings
Human studies link chronic obstructive pulmonary disease with altered levels of IL-4, IL-5, IL-6, and IL-12p70 in high-risk individuals, as well as PRODH2 in patients with sarcopenia.
- Human trial1
- Humans1
- Animals1
Associations
5PRODH2
upin humans1
1 study
PRODH2
upin humans1
PRODH2 is associated with chronic obstructive pulmonary disease in humans.
Humansin sarcopenic COPD patients
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice · Aging cell · 1 Oct 2026
IL-12p70
upin humans1
1 study
IL-12p70
upin humans1
IL-12p70 is associated with chronic obstructive pulmonary disease in humans.
Humanshigh-risk individuals (COPD-SQ ≥ 16, preserved lung function)n = 89
Age-linked immune profiles identify distinct risk groups for chronic obstructive pulmonary disease · Journal of inflammation research · 22 Sep 2026
IL-6
upin humans1
1 study
IL-6
upin humans1
IL-6 is associated with chronic obstructive pulmonary disease in humans.
Humanshigh-risk individuals (COPD-SQ ≥ 16, preserved lung function)n = 89
Age-linked immune profiles identify distinct risk groups for chronic obstructive pulmonary disease · Journal of inflammation research · 22 Sep 2026
IL-5
upin humans1
1 study
IL-5
upin humans1
IL-5 is associated with chronic obstructive pulmonary disease in humans.
Humanshigh-risk individuals (COPD-SQ ≥ 16, preserved lung function)n = 89
Age-linked immune profiles identify distinct risk groups for chronic obstructive pulmonary disease · Journal of inflammation research · 22 Sep 2026
IL-4
upin humans1
1 study
IL-4
upin humans1
IL-4 is associated with chronic obstructive pulmonary disease in humans.
Humanshigh-risk individuals (COPD-SQ ≥ 16, preserved lung function)n = 89
Age-linked immune profiles identify distinct risk groups for chronic obstructive pulmonary disease · Journal of inflammation research · 22 Sep 2026
Latest
3Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · Chen G et al.
Age-linked immune profiles identify distinct risk groups for chronic obstructive pulmonary disease
Clustering four age-associated inflammatory cytokines separated adults into three distinct endotypes tied to early chronic lung disease risk.
Journal of inflammation research · Wu B et al.
A deep learning score for cellular senescence predicts human mortality and disease risk
The proteomic biomarker tracked chronic illness risk in the UK Biobank and shifted following an 18-month multimodal exercise intervention.
Aging cell · Zhao S et al.