Aging in populations: research news, to 27 Sep 2026

Sun 27 Sep1 paper

medRxivHumansPreprint27 Sep

Circadian syndrome is linked to digestive disease in older adults

Circadian syndrome was associated with a 25.7% higher risk of digestive disease in 4,771 Chinese adults followed for a median of 84 months.Circadian syndrome was associated with a 25.7% higher risk of digestive disease in 4,771 Chinese adults followed for a median of 84 months. In a prospective cohort of 4,771 Chinese adults aged 45 and older from the China Health and Retirement Longitudinal Study, researchers evaluated…

Gut and microbiome

Sat 26 Sep106 papers

medRxivHumansPreprint26 Sep

Patterns of modifiable lifestyle, behavioural and health-related risk factors and their associations with incident dementia in UK Biobank

Dementia

Research SquareHumansPreprint26 Sep

Prevalence and Associated Factors of Low Bone Mass Among 937 Nursing Staff at a Tertiary Hospital in China: A Cross-Sectional Study

Bones and joints

Research SquareHumansPreprint26 Sep

Perceived Environmental Barriers and Disability Among Older Adults in the Eastern Himalayan Region of India: A Mixed-Methods Community-Based Study

Research SquareHumansPreprint26 Sep

Physical, psychological and cognitive multimorbidity and fall risk in older adults: a four-country longitudinal cohort analysis

Research SquareResearchPreprint26 Sep

Screening for "Frailty – Sarcopenia – Nutrition - Physical activity" among older population in Henan province, China: a study protocol of a prospective, observational cohort study

Sarcopenia

Research SquareHumansPreprint26 Sep

Factors Associated with Frailty Among Older Adults Receiving Outpatient Care

Depressive symptoms

Research SquareHumansPreprint26 Sep

Mediating role of arterial stiffness and hemodynamic load in the association between obesity and cardiovascular disease risk: a prospective cohort study

Mechanisms

Research SquareHumansPreprint26 Sep

A Dyadic Person-Centered Approach to Family Functioning: Associations with Psychological Well-Being and Cognitive Functioning

DiagnosticsHumans26 Sep

Global and Medial Temporal MRI Morphometry in Alzheimer's Disease and Cognitively Normal Adults: A Retrospective Association Study

Distribution of age by diagnosis and sex.

Alzheimer's disease

HealthcareHumans26 Sep

Sedentary Time and Current Tinnitus in Midlife Korean Women (Aged 40 to 64 Years): A Cross-Sectional Analysis from KNHANES 2014-2018

Participant flow. From 37,306 pooled Korea National Health and Nutrition Examination Survey (KNHANES) 2014–2018 participants, 20,469 were female and 7903 were aged 40–64 years; after exclusion for…

Ear

HealthcareHumans26 Sep

Incremental Information from Repeated Loneliness Assessments in Middle-Aged and Older Adults

Depressive symptoms

HealthcareHumans26 Sep

Muscle Strength Profiles According to Kidney Dysfunction and Anemia Status in Korean Adults Aged ≥40 Years: A Nationwide Cross-Sectional Study

Anemia

HealthcareIn silico26 Sep

Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates

Age-standardised rate of years lived with disability from all causes, Romania, 1990 to 2023.

Diabetes mellitus

HealthcareHumans26 Sep

Impact of Longitudinal Changes in Dynamic Lower-Limb Function on Care-Needs Certification: A 4-Year Prospective Study of Older Women Attending Community Gathering Places (Kayoi-no-ba)

HealthcareHumans26 Sep

Differential Associations of Healthy Lifestyle Latent Classes with Glycemic Transitions in Prediabetes: An Observational Study Based on CHARLS

Flow chart of the study participant selection process.

Prediabetes

HealthcareHumans26 Sep

Association Between Physical Activity Levels and Life Functioning in Korean Older Adults: A Cross-Sectional Analysis of the 2024 Korea National Health and Nutrition Examination Survey

Flowchart of participant selection from the 2024 Korea National Health and Nutrition Examination Survey (KNHANES).

HealthcareHumans26 Sep

Additive Burden of Low Peak Expiratory Flow and Sleep Disturbance on Incident Depressive Symptoms in Later Life: A Four-Cohort Longitudinal Study of 49,201 Participants

Study design. Baseline assessment of peak expiratory flow and sleep disturbance at each cohort’s baseline wave; classification into four mutually exclusive joint exposure groups; cohort-specific…

Depressive symptoms

Brain SciencesHumans26 Sep

Cognitive and Behavioral Functioning in Female Former Soccer Players: Results from the Head Impact and Trauma Surveillance Study (HITSS)

Sample derivation and task completion rates.

Brain SciencesHumans26 Sep

Neuropsychological Correlates of Anxiety in Older Adults: A Cross-Sectional Comparison with Controls Without a Psychiatric Diagnosis

Anxiety

GenesHumans26 Sep

Potential Association Between Basal Metabolic Rate and Presbyopia: A Two-Sample Mendelian Randomisation Study

Diagram of two-sample Mendelian randomisation analysis.

Eye

BiomedicinesHumans26 Sep

Irritable Bowel Syndrome and Incident Hypertension: Epidemiologic and Genetic Insights

Hypertension

BiomedicinesHumans26 Sep

Associations of Elevated Lipoprotein(a) with C-Reactive Protein and Type 2 Diabetes in a Multiethnic Population

Circulation levels of Lp(a) in the entire study population stratified by (a). gender, (b). ethnicity, and (c). diabetes status.

Type 2 diabetes

BiomedicinesHumans26 Sep

Associations of General and Central Obesity with Cardiovascular Risk by Menopausal and MASLD Status

Flowchart of the participant recruitment process.

Metabolic dysfunction-associated steatotic liver disease

BiomedicinesIn silico26 Sep

Long-Term Impact of Historical BCG Vaccination Policies on Parkinson's Disease Risk: A Hypothesis-Generating Retrospective Cohort Analysis

Selected matrix of single-year birth cohorts generated by interpolation of missing values between actual PD AAIR values from Balash et al., showing quintets of 5 age groups, each presenting their…

Parkinson's disease

Behavioral SciencesHumans26 Sep

The Impact of Working Beyond Retirement on Cognitive Function Among the Retirement-Transition Population

Basic model of cognitive reserve theory.

AntioxidantsHumans26 Sep

Dietary (Poly)phenol Intake, Inflammatory Biomarkers, and Mild Cognitive Impairment in Italian Adults

Mild cognitive impairment

BioengineeringHumans26 Sep

Mobile Phone Call Duration and Cardiovascular Outcomes: Prospective and Genetic Evidence on a Potential Depression-Related Pathway

Coronary artery disease

BioengineeringHumans26 Sep

Long-Term Air Pollution Exposure, Cardiovascular Disease, and Cardiometabolic Risk Factors in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study

Global disease burden attributable to air pollution.

Dyslipidemia

The Journals of Gerontology, Series BHumans26 Sep

Moment-to-Moment Performance and Nightly Subjective Assessments: Multi-Timescale Associations Between Subjective Age and Cognitive Function

Respiratory ResearchHumans26 Sep

Frailty and longitudinal pulmonary function trajectories in lung transplant recipients

Baseline pulmonary function according to baseline frailty score Notes: Relationship between baseline frailty score and pulmonary function parameters, including forced vital capacity (FVC), forced…

Lung

BMC MedicineHumans26 Sep

Biological signature of dietary patterns in older adults: findings from a population-based study

Volcano plots displaying the association between adherence to the Alternative Mediterranean Diet (AMED) (per 1-SD increment) and blood-based biomarkers at the median (50th percentile) of the…

Blood and immune system

GeroScienceHumans26 Sep

Diet benefits for epigenetic aging may reflect familial factors

In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over…In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over 12 years. In adult Danish monozygotic twins from the GEMINAKAR cohort, researchers evaluated whether adherence to dietary guidelines is…

International PsychogeriatricsHumans26 Sep

The association between depressive disorders and dementia in very old adults - A longitudinal 5-year follow-up study

Dementia

Sleep HealthHumans26 Sep

Insomnia with objective short sleep duration, objective long sleep duration, and mortality in older persons

Insomnia

BMJ OpenHumans26 Sep

Low bone status on calcaneal quantitative ultrasound among community screening attendees in rural northern Vietnam: a cross-sectional study

Proportion of participants with low bone status on calcaneal quantitative ultrasound (QUS) by age group and sex.

Bones and joints

Advances in Medical SciencesHumans26 Sep

Metals and metalloids signatures in early pregnancy suggest cadmium and arsenic as major mixture components associated with gestational diabetes mellitus risk

Gestational diabetes mellitus

Geriatric NursingHumans26 Sep

Aging patterns based on the difference between physical fitness age and chronological age are associated with physical, mental, and cognitive health in older adults

Biomarkers

Journal of Infection and Public HealthHumans26 Sep

Association between cervical human papillomavirus infection and bladder cancer risk: A community-based cohort study

Bladder cancer

Archives of Gerontology and GeriatricsHumans26 Sep

Trends in statin use and its association with mortality among older U.S. cancer survivors with and without coronary heart disease

Coronary heart disease

Journal of Clinical AnesthesiaHumans26 Sep

The Co-TELE-SURGE study: A prospective cohort proof-of-concept study of perioperative cognitive trajectories in older adults undergoing noncardiac surgery

PLOS Digital HealthHuman trial26 Sep

Optimizing accelerometer implementation in a gerotherapeutic trial: Feasibility, adherence, and operational insights of ABLE

Interventions

PLOS OneHumans26 Sep

Loneliness and all-cause mortality in the United States

PLOS OneHumans26 Sep

The impact of adverse childhood experiences on the development of multimorbidity in older adults in Nigeria

Percent (%) distribution of various types of ACE in the study sample.

Multimorbidity

Kidney & Blood Pressure ResearchHumans26 Sep

Serum Uric Acid and Blood Urea Nitrogen as Primary Determinants of eGFR in 23,960 Chinese Adults: A Cross-Sectional Study with Machine Learning and Longitudinal Validation

eGFR

Clinical Spine SurgeryHumans26 Sep

Age-Specific Risk Factors and Time to New Vertebral Fractures After Percutaneous Vertebral Augmentation: Insights From a Retrospective Study

Bones and joints

Journal of NeuropsychologyHumans26 Sep

Factors associated with functional dependence in older adults with disabilities in Brazil: a study based on the 2019 National Health Survey

Ciencia & Saude ColetivaHumans26 Sep

Associations of light smoking with serum carcinoembryonic antigen and relative leukocyte telomere length in men with asthma

Lung

Tobacco Induced DiseasesHumans26 Sep

Association between urinary NNAL concentrations and osteoarthritis: Evidence from NHANES 2007-2012

Osteoarthritis

Frontiers in Molecular NeuroscienceHumans26 Sep

Cognitive-behavioral phenotypes in FMR1 premutation carriers: a cross-population comparison with mild cognitive impairment

Mild cognitive impairment

Medical Research ArchivesHumans26 Sep

Exploring the Relationship Between Dolutegravir and Diabetes Using Routine Data of Patients on Anti-Retroviral Treatment in a High HIV Prevalence Setting

Type 2 diabetes

Journal of Health Economics and Outcomes ResearchHumans26 Sep

Real-World Adherence and Follow-Up Colonoscopy After Multitarget Stool DNA Screening in a Regional Healthcare System

Colorectal cancer

Frontiers in Public HealthHumans26 Sep

Longitudinal co-development of social interaction, physical frailty, and subjective cognitive decline among community-dwelling older adults in Japan: a six-year parallel growth study

Mild cognitive impairment

American Journal of Cardiovascular DiseaseHumans26 Sep

Association between coronary artery calcification and cardiometabolic, hepatic, and renal markers in a Chinese population undergoing health examinations

Open Forum Infectious DiseasesHumans26 Sep

Increasing Multimorbidity Burden After COVID-19 Infection Among People With and Without HIV in the United States: Insights From the National Clinical Cohort Collaborative (N3C)

COVID-19

Journal of Diabetes and Metabolic DisordersHumans26 Sep

Breast cancer and diabetes mellitus-related mortality among U.S. adults: a 25-year CDC WONDER analysis (1999-2023)

Diabetes mellitus

Alzheimer's & DementiaHumans26 Sep

Extracerebral microvascular burden links to dementia risk and brain structural changes: Evidence from a large-scale cohort study

Dementia

Frontiers in Public HealthHumans26 Sep

Cardiometabolic multimorbidity and cognitive-functional transitions across international ageing cohorts

Heart disease

Frontiers in Public HealthHumans26 Sep

Trajectories of blood pressure measures and the incidence of electrocardiographic abnormalities: a worker-based cohort study

Frontiers in NutritionHumans26 Sep

Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging

Frontiers in Public HealthHumans26 Sep

Hypertension prevention attitudes and propensity to achieve a healthy lifestyle in young and middle-aged adults at increased risk: a cross-sectional study

Hypertension

Frontiers in NutritionHumans26 Sep

Dietary patterns and osteoporosis risk in a high-altitude population: the roles of gut microbiota and plasma metabolites in a case-control study

Osteoporosis

Frontiers in NutritionHumans26 Sep

Ultra-processed food consumption and atherosclerosis risk: a prospective cohort study of UK Biobank

Atherosclerosis

Frontiers in NutritionHumans26 Sep

Association of the CUN-BAE index with glycemic outcomes in individuals with impaired fasting glucose: a retrospective multicenter Chinese cohort study

Type 2 diabetes

Wellcome Open ResearchResearch26 Sep

Ethnic differences in the patterns, incidence and prevalence of multiple long-term conditions: a systematic review protocol

Ethnicity & HealthHumans26 Sep