Triglyceride-glucose index

1. Triglyceride-glucose index improves premature myocardial infarction risk discrimination in humans (ΔAUC 0.050, bootstrap 95% CI 0.002-0.096).

   “Adding the TyG index to the clinical model increased the AUC from 0.647 to 0.696 (ΔAUC = 0.050; DeLong p = 0.046).”

   Humansadding TyG index to clinical modeln = 228

   Association of the Triglyceride-Glucose Index with Premature Myocardial Infarction in a Propensity Score-Matched Non-Diabetic Population · Diagnostics (Basel, Switzerland) · 16 Sep 2026

1. Triglyceride-glucose index raises the risk of cardiovascular disease in humans.

   Humans11.08 yearsn = 46,827

   Comparative associations of cumulative cholesterol-HDL-glucose index and triglyceride-glucose index with risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study · Frontiers in endocrinology · 18 Sep 2026

2. Triglyceride-glucose index raises the risk of cardiovascular disease in humans.

   Humansgeneral population

   Predictive value of the triglyceride-glucose index combined with novel body shape indices for cardiovascular disease: a cross-sectional study based on NHANES · European review for medical and pharmacological sciences · 1 Sep 2026

3. Triglyceride-glucose index raises the risk of cardiovascular disease in humans (adjusted HR = 4.597).

   “the TyG index remained strongly associated with incident CVD (adjusted HR = 4.597, p”

   Humans12-29 monthsn = 553

   Association Between the Triglyceride-Glucose Index and Incident Cardiovascular Disease in Non-diabetic Adults: A Prospective Cohort Study · Cureus · 26 Aug 2026

Cardiovascular disease →

1. Triglyceride-glucose index predicts pre-metabolic syndrome in humans (AUC 0.731 (95% CI 0.718–0.744)).

   Humansn = 8,997

   Diagnostic Value of Insulin Resistance Indices and Nomogram Models in Identifying Pre-Metabolic Syndrome: A Population-Based Study from Southeast China · Research Square · 29 Sep 2026 · Preprint

Pre-metabolic syndrome →

1. Triglyceride-glucose index raises the risk of cardiometabolic multimorbidity in humans (P < 0.001).

   Humansprospective cohortmean 9.27-year follow-upn = 6,092

   Combined associations of triglyceride-glucose index and biochemical sarcopenia index with cardiometabolic multimorbidity in middle-aged and older Chinese adults · Maturitas · 26 Sep 2026

Cardiometabolic multimorbidity →

1. Triglyceride-glucose index raises the risk of coronary artery disease in humans (HR 1.57 (95% CI 1.51-1.63)).

   HumansQ4 versus Q1

   Insulin Resistance Indices and Genetic Predisposition in Relation to the Risk of Incident and Recurrent Coronary Artery Disease · Journal of the American Heart Association · 24 Sep 2026

Coronary artery disease →

1. Triglyceride-glucose index raises the risk of gestational diabetes mellitus in humans (OR 3.747, 95% CI 1.010-13.894; p = 0.048).

   “TyG (OR 3.747, 95% CI 1.010-13.894; p = 0.048) were associated with increased GDM odds”

   Humansplasma-serum11+0-13+6 weeks

   Integrated First-Trimester Assessment of Placental Biomarkers, Metabolic Indices, and IGF-1/IGFBP-5 in Relation to Subsequent Gestational Diabetes Mellitus: A Prospective Cohort Study · Medicina (Kaunas, Lithuania) · 19 Sep 2026

Gestational diabetes mellitus →

1. Triglyceride-glucose index raises the risk of myocardial infarction in humans (adjusted OR 2.704, 95% CI 1.408-5.192).

   “The TyG index was independently associated with premature MI in conditional logistic regression (adjusted OR 2.704, 95% CI 1.408-5.192; p = 0.003).”

   Humansnon-diabetic adults, matched for age, sex, BMI, smoking, hypertensionn = 228

   Association of the Triglyceride-Glucose Index with Premature Myocardial Infarction in a Propensity Score-Matched Non-Diabetic Population · Diagnostics (Basel, Switzerland) · 16 Sep 2026

Myocardial infarction →

1. Triglyceride-glucose index raises the risk of hypertension-diabetes comorbidity in humans (OR 3.16 (95% CI 2.75-3.64) per 1-SD).

   Humans

   Association of the TyG-related indices with hypertension-diabetes comorbidity in middle-aged and older adults: a suburban community-based study · BMC cardiovascular disorders · 25 Jul 2026

Hypertension-diabetes comorbidity →