Populations
Mon 28 Sep90 papers
Age-Specific Associations Between the Testosterone-to-Estradiol Ratio and Metabolic Syndrome Components in Middle-Aged and Elderly Chinese Men
Lower oral frailty linked to greater independence in older adults
Simulating a stepwise drop in oral frailty yielded a 73% higher probability of being alive and functionally independent (probability ratio 1.73, 95%…Simulating a stepwise drop in oral frailty yielded a 73% higher probability of being alive and functionally independent (probability ratio 1.73, 95% CI 1.48–2.02). In a cohort of 1,702 community-dwelling adults aged 60 or older in Florianópolis, Brazil, followed from 2009 to 2023…
Lewy body disease tracks with cognitive decline and psychosis
Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains. Researchers analyzed 2,480 autopsied brains from participants aged 73.25 years on average in the Biobank for Aging Studies in São Paulo…
Early-onset blood cancer risks associated with living near superfund sites
Risk factors for colorectal carcinoma; a hospital-based study
Peak oxygen uptake falls in older cyclists over nine years
In 82 older cyclists followed across nine years, peak oxygen consumption fell 19.7%, dropping from 44.1 to 35.4 ml·kg⁻¹·min⁻¹.In 82 older cyclists followed across nine years, peak oxygen consumption fell 19.7%, dropping from 44.1 to 35.4 ml·kg⁻¹·min⁻¹. In a cohort of older human cyclists, researchers examined how nine years of continued cycling exercise affected physiological aging.
Body Weight Change and Dementia Risk in Young and Middle-Aged Adults With Type 2 Diabetes and Depression: A Nationwide Cohort Study
Kidney dysfunction links to higher cognitive impairment risk
In 1,195 older adults followed for three years, impaired kidney function raised incident cognitive impairment odds (OR = 1.744) compared to normal…In 1,195 older adults followed for three years, impaired kidney function raised incident cognitive impairment odds (OR = 1.744) compared to normal function. Chinese older adults aged 65 and older with kidney dysfunction face an increased risk of developing cognitive impairment, according…
Physical Performance and Central Nervous System-Active Analgesics Independently Predict 8-Year Fall Risk in Adults with or at Risk for Knee Osteoarthritis
Ten-year progression of white matter hyperintensities according to baseline hypertensive retinopathy in a population-based cohort
Nocturia links to higher mortality in CKM syndrome
Nocturia prevalence rose from 17.6% in stage 0 to 45.97% in stages 3-4 across 11,910 NHANES participants, independently predicting all-cause and…Nocturia prevalence rose from 17.6% in stage 0 to 45.97% in stages 3-4 across 11,910 NHANES participants, independently predicting all-cause and cardiovascular mortality. In a study of 11,910 NHANES participants and 865 hospital patients, researchers evaluated nocturia across stages of…
Frailty tied to loss of independence after low-stress surgery
In frail patients undergoing low-stress procedures, the loss of independence rate was 11%, with frailty associated with higher odds of non-home…In frail patients undergoing low-stress procedures, the loss of independence rate was 11%, with frailty associated with higher odds of non-home discharge (odds ratio 4.6). In a retrospective study of 13,674 surgical patients aged over 50 years undergoing elective inpatient procedures…
Nonlinear Association Between Serum Uric Acid and Incident Stroke in Patients with Diabetes: A Two-Centre Cohort Study
Visual impairment severity links to higher dementia risk
Severe visual impairment was associated with dementia onset 2.1 years earlier than normal vision in a 16-year cohort of older adults.Severe visual impairment was associated with dementia onset 2.1 years earlier than normal vision in a 16-year cohort of older adults. A territory-wide cohort study followed 15,576 community-dwelling older adults without dementia at baseline for 16 years.
Age-Related Variations in Clinical and Biochemical Profiles of People Living With HIV
Cognitive and physical deficits link to worsening depression
In 8,473 older adults, having both deficits carried a hazard ratio of 1.76 for developing mild depressive symptoms and 0.82 for symptom reversion.In 8,473 older adults, having both deficits carried a hazard ratio of 1.76 for developing mild depressive symptoms and 0.82 for symptom reversion. In a study of 8,473 Chinese adults aged 60 and older from the China Health and Retirement Longitudinal Study, researchers evaluated how…
What Increases the Likelihood of Dementia Among Asian Americans? Analysis of Nativity and Life Course Factors
Older adult suicide deaths rose across the Americas
Total deaths rose from 13,567 in 2000 to 27,792 in 2023, while regional rates shifted slightly from 14.46 to 14.95 per 100,000.Total deaths rose from 13,567 in 2000 to 27,792 in 2023, while regional rates shifted slightly from 14.46 to 14.95 per 100,000. In adults aged 60 and older across 38 countries and territories in the Americas, researchers evaluated suicide mortality patterns from 2000 to 2023 using Global…
Metabolic and vascular markers linked to angle-closure glaucoma
A study of 499,102 adults in China over 15.7 years identified 26 factors linked to probable primary angle-closure glaucoma, including diabetes and…A study of 499,102 adults in China over 15.7 years identified 26 factors linked to probable primary angle-closure glaucoma, including diabetes and elevated pulse pressure. In a prospective cohort of 499,102 adults aged 30 to 79 from the China Kadoorie Biobank, researchers tracked probable…
Activity fragmentation predicts mortality risk in adults
In US adults, each standard-deviation rise in activity fragmentation was linked to a 19% higher hazard of death after adjusting for activity volume.In US adults, each standard-deviation rise in activity fragmentation was linked to a 19% higher hazard of death after adjusting for activity volume. In a prospective cohort of 5,973 United States adults aged 20 or older, researchers examined whether activity fragmentation predicted…
Joint word recall and functional limitation among selected SHARE participants with prior survey-identified stroke versus a stroke-free reference group
APOE ε4 associates with epilepsy, dementia, and higher mortality
In UK Biobank participants, carrying one or two APOE ε4 copies was linked to approximately 80% and 225% higher risks of post-epilepsy dementia.In UK Biobank participants, carrying one or two APOE ε4 copies was linked to approximately 80% and 225% higher risks of post-epilepsy dementia. In a cohort of UK Biobank participants, researchers evaluated how apolipoprotein E (APOE) ε4 status relates to epilepsy risk, post-epilepsy…
Epigenetic age acceleration tracks lower baseline cognition and greater retest gains
In middle-aged adults, biological aging correlated with processing speed variability and baseline performance but did not predict cognitive change…In middle-aged adults, biological aging correlated with processing speed variability and baseline performance but did not predict cognitive change over time. In a study of 139 adults aged 25 to 65, researchers investigated how DNA methylation measures of biological age relate to specific…
Depression profiles link to cognitive and functional decline
In over 28,000 older adults, specific symptom configurations predicted lower cognition and higher daily living limitations four years later beyond…In over 28,000 older adults, specific symptom configurations predicted lower cognition and higher daily living limitations four years later beyond overall symptom severity. In a study of adults aged 50 years and older, researchers analyzed 68,854 person-wave observations from 28,042…
Poor sleep is linked to complex coronary plaques in young adults
In 3,983 patients aged 40 or younger, functional ischemia rose from 9.6% in favorable sleepers to 31.9% in those with poor sleep.In 3,983 patients aged 40 or younger, functional ischemia rose from 9.6% in favorable sleepers to 31.9% in those with poor sleep. In a retrospective study of 3,983 young adults aged 40 or younger who underwent coronary CT angiography, researchers examined how sleep patterns and shift work…
Higher body roundness trajectories linked to hypertension risk
In non-diabetic older adults, an increasing body roundness trajectory had an odds ratio of 1.76 for incident hypertension compared with a low-level…In non-diabetic older adults, an increasing body roundness trajectory had an odds ratio of 1.76 for incident hypertension compared with a low-level pattern. In 4,522 non-diabetic Chinese adults aged 45 and older from the CHARLS cohort, researchers modeled body roundness index trajectories…
Proteomic insights into childhood adversity: Exploring biological mechanisms and cognitive outcomes in the CARDIA study
Cognitive ageing among older Latin American immigrants: current evidence and limitations
Masculinity, Lifestyle Factors, and Andropause-Related Symptoms in Pakistani Men: A Cross-Sectional Study
Cumulative non-HDL cholesterol is linked to CVD risk
Each 100-unit increase in cumulative exposure was associated with an adjusted hazard ratio of 1.07 for cardiovascular disease over nine years, driven…Each 100-unit increase in cumulative exposure was associated with an adjusted hazard ratio of 1.07 for cardiovascular disease over nine years, driven by earlier stages. In a nationwide study of 5,283 middle-aged and older adults in China, cumulative exposure to non-HDL cholesterol was…
Factors associated with sarcopenia in elderly patients with type 2 diabetes mellitus
Chronic Stress and Its Association with Elevated Blood Pressure and Lifestyle Habits among Medical Students
Multimorbidity and Essential Dental Care Needs: Results From the 2003 and 2016-2017 Chilean National Health Survey
Depression and physical decline track together in older adults
Tracking 8,961 adults aged 45 and older over seven years revealed four joint trajectories of depressive symptoms, chronic conditions, pain, and…Tracking 8,961 adults aged 45 and older over seven years revealed four joint trajectories of depressive symptoms, chronic conditions, pain, and functional disability. In middle-aged and older Chinese adults, depressive symptoms and multiple physical health problems evolve along four…
Nutrient deficits linked to higher metabolic risks in obesity
Compared to patients without nutritional deficiencies, vitamin D and B12 deficits carried median hazard ratios of 3.09 and 2.49 for metabolic diseases…Compared to patients without nutritional deficiencies, vitamin D and B12 deficits carried median hazard ratios of 3.09 and 2.49 for metabolic diseases in obesity. In electronic health records from the U.S.
Clinical Outcomes According to Age and Atrial Fibrillation Type: Insights from the Multicentre REGUEIFA Registry
Early physical therapy links to lower mortality in heart failure
Early outpatient physical therapy was associated with lower 1-year all-cause mortality than no therapy, with a hazard ratio of 0.46.Early outpatient physical therapy was associated with lower 1-year all-cause mortality than no therapy, with a hazard ratio of 0.46. Researchers analyzed 6,359 older adults hospitalized for worsening heart failure and chronic kidney disease across 96 institutions in Japan.
Beyond Menopausal Stage: Symptom Burden, Self-Efficacy, and Psychological Distress
Environmental Pollution, Biomarkers, and Dementia: An Evidence Review
A Thematic Narrative Review of Osteoarthritis Risk Factors Across the Female Life Course
