Coronary artery disease

Disease20 papers10 findingsMeSH D003324

  • Human trial2
  • Humans12
  • In silico1

Effects

3

Digits Forward performance

downin humans1

1 study
  1. Coronary artery disease impairs digits Forward performance in humans (b = 0.386; 95% CI, 0.028 to 0.744; P = 0.035; q = 0.210).

    Humansmultivariable linear regression adjusted for age, sex, and HIV statusn = 512

    Coronary artery disease and neurocognitive performance among older adults in Uganda · Research square · 10 Sep 2026 · Preprint

Color Trails 2 performance

downin humans1

1 study
  1. Coronary artery disease impairs color Trails 2 performance in humans (b = 0.502; 95% CI, 0.184 to 0.821; P = 0.002; q = 0.026).

    Humansmultivariable linear regression adjusted for age, sex, and HIV statusn = 512

    Coronary artery disease and neurocognitive performance among older adults in Uganda · Research square · 10 Sep 2026 · Preprint

Global cognition

no changein humans1

1 study
  1. Coronary artery disease has no effect on global cognition in humans (b = 0.093 SD units; 95% CI, - 0.122 to 0.308; P = 0.397).

    Humansmultivariable linear regression adjusted for age, sex, and HIV statusn = 512

    Coronary artery disease and neurocognitive performance among older adults in Uganda · Research square · 10 Sep 2026 · Preprint

Upstream

1

Frailty-related metabolic signature

mediatesin humans1

1 study
  1. Frailty-related metabolic signature mediates coronary artery disease in humans (18.5%, 95% CI 15.7-21.7).

    Humans14.8 years

    Metabolic signature links frailty to coronary artery disease · The journal of nutrition, health & aging · 3 Oct 2026

Frailty-related metabolic signature →

Associations

6

Frailty

upin humans1HR 1.78

1 study
  1. Frailty raises the risk of coronary artery disease in humans (HR 1.78, 95% CI 1.59-1.99).

    Humans14.8 yearsn = 223,907

    Metabolic signature links frailty to coronary artery disease · The journal of nutrition, health & aging · 3 Oct 2026

Triglyceride-glucose index

upin humans1HR 1.57

1 study
  1. Triglyceride-glucose index raises the risk of coronary artery disease in humans (HR 1.57 (95% CI 1.51-1.63)).

    HumansQ4 versus Q1

    Insulin Resistance Indices and Genetic Predisposition in Relation to the Risk of Incident and Recurrent Coronary Artery Disease · Journal of the American Heart Association · 24 Sep 2026

Triglyceride-glucose index →

APOE

upin humans1

1 study
  1. APOE raises the risk of coronary artery disease in humans (OR ~1.5).

    Reviewadjusted, ε3/ε3-referenced

    Apolipoprotein E ε3/ε4 and coronary artery disease: lipid and non-lipid mechanisms in personalized prevention - narrative review · Frontiers in cardiovascular medicine · 18 Sep 2026

APOE →

Breast arterial calcification

upin reviews1

1 study
  1. Breast arterial calcification raises the risk of coronary artery disease.

    Reviewparticularly in women with hypertension

    Automated assessment of breast arterial calcification: a new frontier in cardiovascular risk prediction · Frontiers in cardiovascular medicine · 18 Sep 2026

Mobile phone call duration

upin humans1HR 1.18

1 study
  1. Mobile phone call duration raises the risk of coronary artery disease in humans (HR 1.18, 95% CI 1.10-1.27).

    “call duration greater than 6 h/week was associated with CAD (HR 1.18, 95% CI 1.10-1.27)”

    Humans> 6 h/week

    Mobile Phone Call Duration and Cardiovascular Outcomes: Prospective and Genetic Evidence on a Potential Depression-Related Pathway · Bioengineering (Basel, Switzerland) · 5 Sep 2026

Mobile phone call duration →

Low-density lipoprotein cholesterol

upin humans1HR 1.24

1 study
  1. Low-density lipoprotein cholesterol raises the risk of coronary artery disease in humans (HR 1.24, 95% CI 1.21-1.26).

    Humans13 yearsn = 468,266

    Risk factors for atherosclerosis diverge across vascular beds · American journal of preventive cardiology · 19 Jun 2026

Low-density lipoprotein cholesterol →

Latest

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American Journal of Preventive CardiologyHumans

Risk factors for atherosclerosis diverge across vascular beds

Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent…Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent polyvascular spread and mortality.

The Journal of Nutrition, Health & AgingHumans

Metabolic signature links frailty to coronary artery disease

A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year…A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.

Advanced ScienceIn silico

Facial foundation model estimates clinical biomarkers

Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across…Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across four cohorts.

Journal of Clinical LipidologyHumans

Estimated sdLDL-C predicts cardiovascular risk in Japanese adults

In over 1.8 million Japanese adults, the highest quartile of estimated sdLDL-C carried an ASCVD hazard ratio of 1.25 compared with the lowest.In over 1.8 million Japanese adults, the highest quartile of estimated sdLDL-C carried an ASCVD hazard ratio of 1.25 compared with the lowest.