Intrinsic capacity
Biomarker7 papers7 findings
- Humans7
Upstream
1Age
downin humans1
1 study
Age
downin humans1
age decreases intrinsic capacity in humans (67 to 61 on a 0-100 scale).
Humans15-year
Developing and validating intrinsic capacity scores in early adulthood and midlife: 15-year follow-up from the Northern Finland Birth Cohort 1966 · Experimental gerontology · 25 Sep 2026
Associations
6Functional limitations
downin humans1OR 0.69–0.82
1 study
Functional limitations
downin humans1OR 0.69–0.82
Intrinsic capacity predicts functional limitations in humans (OR 0.69-0.82 per 10-point increase).
Humans15 years
Developing and validating intrinsic capacity scores in early adulthood and midlife: 15-year follow-up from the Northern Finland Birth Cohort 1966 · Experimental gerontology · 25 Sep 2026
Cardiovascular disease
downin humans1OR 0.69–0.82
1 study
Cardiovascular disease
downin humans1OR 0.69–0.82
Intrinsic capacity predicts cardiovascular disease in humans (OR 0.69-0.82 per 10-point increase).
Humans15 years
Developing and validating intrinsic capacity scores in early adulthood and midlife: 15-year follow-up from the Northern Finland Birth Cohort 1966 · Experimental gerontology · 25 Sep 2026
Type 2 diabetes
downin humans1OR 0.69–0.82
1 study
Type 2 diabetes
downin humans1OR 0.69–0.82
Intrinsic capacity predicts type 2 diabetes in humans (OR 0.69-0.82 per 10-point increase).
Humans15 years
Developing and validating intrinsic capacity scores in early adulthood and midlife: 15-year follow-up from the Northern Finland Birth Cohort 1966 · Experimental gerontology · 25 Sep 2026
Edentulism
downin humans1HR 0.609
1 study
Edentulism
downin humans1HR 0.609
Intrinsic capacity lowers the risk of edentulism in humans (HR = 0.609, 95% CI: 0.403-0.919).
Humanscompared to lowest IC category (scores 0-1)
Association Between Intrinsic Capacity and Edentulism in Middle-Aged and Older Adults: A Longitudinal Cohort Study From CHARLS · Journal of oral rehabilitation · 24 Sep 2026
Mortality
downin humans1HR 0.84
1 study
Mortality
downin humans1HR 0.84
Intrinsic capacity lowers the risk of mortality in humans (HR 0.84, 95% CI 0.82-0.85).
Humansfully adjusted modeln = 7,168
Intrinsic capacity predicts mortality better than frailty index · Frontiers in public health · 16 Sep 2026
Incident disability
downin humans1OR 0.79
1 study
Incident disability
downin humans1OR 0.79
Intrinsic capacity lowers the risk of incident disability in humans (OR 0.79, 95% CI 0.74-0.84).
Humansfully adjusted modeln = 7,168
Intrinsic capacity predicts mortality better than frailty index · Frontiers in public health · 16 Sep 2026
Latest
9Multiple chronic conditions link to lower intrinsic capacity
In pooled data from older adults in China, multiple chronic conditions were associated with lower intrinsic capacity (β = -0.076).In pooled data from older adults in China, multiple chronic conditions were associated with lower intrinsic capacity (β = -0.076).
Heatwaves linked to declining intrinsic capacity in older adults
Each extra heatwave day was associated with a relative risk ratio of 1.035 for falling into the lowest intrinsic capacity trajectory in older adults.Each extra heatwave day was associated with a relative risk ratio of 1.035 for falling into the lowest intrinsic capacity trajectory in older adults.
Intrinsic capacity predicts mortality better than frailty index
Higher intrinsic capacity lowered mortality risk (HR = 0.84 against 1.25 per 0.1 frailty increase) and remained predictive after adjusting for frailty…Higher intrinsic capacity lowered mortality risk (HR = 0.84 against 1.25 per 0.1 frailty increase) and remained predictive after adjusting for frailty index.
Dose-Response Relationship Between Physical Activity and Intrinsic Capacity Decline Among Hospitalised Older Patients
Adverse Childhood Experiences and Longitudinal Changes in Intrinsic Capacity in Older Chinese Adults: The Role of Social Support
Living Longer after Labor Market Exit: Making Functional Healthspan a Public Health Nursing Priority
Intrinsic capacity outperforms frailty in cardiac rehab outcomes
In 551 older patients, intrinsic capacity showed a stronger link to post-rehabilitation walking outcomes (β = 0.571) than the frailty index (β =…In 551 older patients, intrinsic capacity showed a stronger link to post-rehabilitation walking outcomes (β = 0.571) than the frailty index (β = -0.281).