Depressive symptoms
Disease7 papers6 findings
- Humans6
Associations
6Cardiometabolic multimorbidity
upin humans1HR 1.25
1 study
Cardiometabolic multimorbidity
upin humans1HR 1.25
Cardiometabolic multimorbidity raises the risk of depressive symptoms in humans (HR 1.25, 95% CI 1.05–1.49).
Humansadjusted for demographic characteristics, lifestyle factors, clinical variables, and laboratory biomarkers2011 through 2020n = 10,726
Cardiometabolic multimorbidity tied to depression in older adults · Research Square · 30 Sep 2026 · Preprint
Estimated pulse wave velocity
upin humans1HR 1.73
1 study
Estimated pulse wave velocity
upin humans1HR 1.73
Estimated pulse wave velocity raises the risk of depressive symptoms in humans (HR 1.73, 95% CI 1.66-1.80).
Humans
Independent and joint predictive value of Lipid Accumulation Product and estimated Pulse Wave Velocity for incident depressive symptoms: Evidence from CHARLS · Journal of affective disorders · 26 Sep 2026
Lipid Accumulation Product
upin humans1HR 1.04
1 study
Lipid Accumulation Product
upin humans1HR 1.04
Lipid Accumulation Product raises the risk of depressive symptoms in humans (HR 1.04, 95% CI 1.03-1.05).
Humans
Independent and joint predictive value of Lipid Accumulation Product and estimated Pulse Wave Velocity for incident depressive symptoms: Evidence from CHARLS · Journal of affective disorders · 26 Sep 2026
Sleep disturbance
upin humans1
1 study
Sleep disturbance
upin humans1
Sleep disturbance raises the risk of depressive symptoms in humans (aRR 1.27).
“component associations were smaller (low PEF only aRR 1.14; sleep disturbance only 1.27)”
Humanssleep disturbance onlyn = 49,201
Additive Burden of Low Peak Expiratory Flow and Sleep Disturbance on Incident Depressive Symptoms in Later Life: A Four-Cohort Longitudinal Study of 49,201 Participants · Healthcare (Basel, Switzerland) · 10 Sep 2026
Low peak expiratory flow
upin humans1
1 study
Low peak expiratory flow
upin humans1
Low peak expiratory flow raises the risk of depressive symptoms in humans (aRR 1.14).
“component associations were smaller (low PEF only aRR 1.14; sleep disturbance only 1.27)”
Humanslow PEF onlyn = 49,201
Additive Burden of Low Peak Expiratory Flow and Sleep Disturbance on Incident Depressive Symptoms in Later Life: A Four-Cohort Longitudinal Study of 49,201 Participants · Healthcare (Basel, Switzerland) · 10 Sep 2026
Low peak expiratory flow and sleep disturbance
upin humans1
1 study
Low peak expiratory flow and sleep disturbance
upin humans1
low peak expiratory flow and sleep disturbance raises the risk of depressive symptoms in humans (pooled aRR 1.40, 95% CI 1.28 to 1.52).
“The joint-exposure group had a higher adjusted rate of incident elevated symptoms in every cohort (pooled aRR 1.40, 95% CI 1.28 to 1.52; I 2 = 41%)”
Humansco-occurring low PEF and sleep disturbancen = 49,201
Additive Burden of Low Peak Expiratory Flow and Sleep Disturbance on Incident Depressive Symptoms in Later Life: A Four-Cohort Longitudinal Study of 49,201 Participants · Healthcare (Basel, Switzerland) · 10 Sep 2026
Latest
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Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity
Depressive symptom profiles and risk of cardiometabolic disease incidence
Exercise benefits on late-life depression differ across nations
A preprint finds physical activity protected against depressive symptoms in US older adults (β = −2.734), but effects varied by education and living…A preprint finds physical activity protected against depressive symptoms in US older adults (β = −2.734), but effects varied by education and living arrangements across countries.
Hobby engagement links to lower functional disability risk
Across cohorts in China, Europe, and Mexico, hobby engagement lowered ADL disability hazard ratios to between 0.73 and 0.82, partly mediated by…Across cohorts in China, Europe, and Mexico, hobby engagement lowered ADL disability hazard ratios to between 0.73 and 0.82, partly mediated by reduced depressive symptoms.
Persistent depression speeds frailty accumulation in older adults
Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of…Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of incident frailty.